FAQ-Enzymes affected by NBE (Bio-male section)

FAQ-Enzymes affected by NBE (Bio-male section) - Printable Version

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FAQ-Enzymes affected by NBE (Bio-male section) - Lotus - 26-04-2014

Enzymes

Dedicated to the NBE team: Understanding these enzymes will unlock a huge NBE potential, good luck!

♦ The level of an enzyme presence in a particular body tissue determines the extent to which the hormone conversion will take place - The amount of a certain hormone in particular areas is a critical factor affecting hormonally related health concerns.

Pharmacokinetics describes how the body affects a specific drug after administration through the mechanisms of absorption and distribution, as well as the chemical changes of the substance in the body (e.g. by metabolic enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug.

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1) Aromatase enzyme CYP19-

There's an enzyme in the bodies of both men and women called aromatase. Its primary action is to produce female sex hormones, or estrogens. It produces them from male sex hormones (androgens) such as testosterone and their precursors.

Aromatase also converts androstenedione (a sex hormone precursor) to the female hormone estrone, another estrogen, although weaker than estradiol.

If you increase the activity of aromatase, you can increase levels of female sex hormones (estradiol, estrone).

If you decrease the activity of aromatase, you can decrease levels of female sex hormones, while increasing relative levels of male sex hormones, e.g. testosterone.

Men's bodies normally contain some level of estrogens, in addition to testosterone and their kind. Likewise, women's bodies contain some level of male androgens including testosterone.

The ratio of male-to-female hormones contributes to our masculinity or femininity. Aromatase is one chemical that can tweak that ratio. It operates the same in both men and women, although an array of compounds can affect its activity.

Herbs that convert aromatase-White Peony, Liorice root, Genistein (PM), BO

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2) 5 alpha-reductase-(enzyme)

Inhibition of 5α-reductase results in decreased conversion of testosterone to DHT, leading to increased testosterone and estradiol. Other enzymes compensate to a degree for the absent conversion, spec voifically with local expression at the skin of reductive 17b-hydroxysteroid dehydrogenase, oxidative 3a-hydroxysteroid dehydrogenase, and 3b-hydroxysteroid dehydrogenase enzymes. Inhibition of the enzyme can be classified into two categories: steroidal, which are irreversible, and nonsteroidal. 5-α reductase 2 is the one we're interested in, there's more but it gets extremely complicated so I'll spare you the gory details.

Herbs that help block 5 ar, licorice, WP, Reishi, SP, pygeum, nettle root, BO (not an herb), Chinese Skullcap, progesterone cream is a strong 5 ar, linolenic acid, green tea
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3) P450 C17-20 enzyme-Cytochrome (17α-hydroxylase)

-P450 enzymes are present in most tissues of the body, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism

Grapefruit juice and herbs that inhibit CYP enzyme system can result in much higher levels of drugs in the bloodstream, and longer persistence of the drugs.

CYPs metabolize thousands of endogenous and exogenous chemicals. Some CYPs metabolize only one (or a very few) substrates, such as CYP19 (aromatase),

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The next two I'll explain later:

4) 17ß-HSD-(17ß-Hydroxysteroid Dehydrogenase)

5) 3ß-HSD (3ß-Hydroxysteroid Dehydrogenase)

Although not an enzyme, Saponins are equally important:

6) Saponins- Saponins are basically phyto-chemicals which are found in most of the vegetables, beans and herbs. The well known sources of saponins are soybeans, peas.

Saponins may improve absorption and elimination of drugs, altering the blood levels and rate of change of drug levels; strongly acid or alkaline herbs may alter absorption of drugs.

RE: FAQ-Enzymes affected by NBE - Lotus - 26-04-2014

(02-04-2014, 06:30 PM)Lotus Wrote: Digestive enzymes at a glance-

http://www.breastnexus.com/attachment.php?aid=6079

RE: FAQ-Enzymes affected by NBE - Lotus - 26-04-2014

One process results in a reduced amount of drug that the body actually ends up utilizing; the other results in an increase in the amount of drug that the body ends up utilizing. Here's how:

First pass metabolism is what occurs when a drug is absorbed from the GI tract. When a drug is taken orally it is absorbed into the portal circulation (the blood vessels of the liver). Many of these drugs are very efficiently metabolized (altered for elimination) as they pass through the portal circulation during this first time. It reduces the amount of active drug that gets into the general circulation. This is first-pass metabolism.

Enterohepatic cycling is where:
Unmetabolized drugs as well as drug metabolites go through the liver and biliary tract for excretion and proceed to make their way out of the body through the intestinal tract. In other words, this is the body's way of putting them in the trash and getting rid of them.
Here's the catch. . .on the way out through the intestines (the entero part of the word enterohepatic) some of the discarded active drug gets reabsorbed back into the blood stream where it is again available to the body for use. In other words, it's being recycled.
RESULT: The half life and duration of action of a drug is increased.

First-pass elimination. Basic concepts and clinical consequences.
http://www.ncbi.nlm.nih.gov/pubmed/6362950

http://wikipedia.org/wiki/First_pass_effect

Drug metabolism
http://en.wikipedia.org/wiki/Drug_metabolism

RE: FAQ-Enzymes affected by NBE - Lotus - 26-04-2014

(26-04-2014, 02:31 AM)EvaMarie Wrote: Thanks Lotus, Im starting to get this I think (I'll try to avoid my blonde wig for a while LOL)

Guess who is going to learn to love grapefruit juice and the fruit itself for breakfast with some oatmeal whether she likes it or not

I found this, thought it was interesting, its EE2 (synthetic not bio identical E2) designed to intentionally be harder to eliminate from the body (potent stuff) nevertheless less Id think the same would apply to E2 whether aromatitzed naturally with NBE or taken in pharma form....

The effects of grapefruit juice on the bioavailability of 17 alpha-ethinylestradiol (EE2) after a single oral administration of 50 micrograms EE2 have been investigated. The pharmacokinetics of EE2 were studied in an open, randomized, cross-over study in which 13 healthy volunteers were administered the drug with herbal tea or grapefruit juice (naringin, 887 mg/ml). In contrast to herbal tea, grapefruit juice increased the peak plasma concentration (Cmax) significantly to 137% (mean; range 64% to 214%, p = 0.0088) and increased the area under plasma concentration-time curve from 0 to 8 hours (AUC0-8) to 128% (mean; range 81% to 180%, p = 0.0186). This study shows that grapefruit juice increases the bioavailable amount of EE2. A possible explanation may be that grapefruit juice inhibits the metabolic degradation of EE2. Whether the increased bioavailability of EE2 following grapefruit juice administration is of clinical importance should be investigated in long-term studies.

http://www.ncbi.nlm.nih.gov/pubmed/8631189

More on grapefruit juice and drug interactions including E2

http://www.alsclinic.com/english/DrugAdministrationGrapefruitJuice.pdf

http://www.livestrong.com/article/108077-estrogen-grapefruit/