Botanicals that mimic or affect DHT, other dihydro-hormones, and 5α-reductase, - Printable Version
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Botanicals that mimic or affect DHT, other dihydro-hormones, and 5α-reductase, - Dynseli - 15-07-2014
Red reishi and green tea reduce 5-alpha-reducatase thereby reducing DHT. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693613/table/tbl2680/?report=objectonly
Pygeum, saw palmetto, and nettle should be looked at to see if they reduce DHT. Verification is needed.
Daidzien is a phytochemical that is said to be estrogenic. but I believe it may act like DHT. A herb or phytochemical that increases body hair is suspect. A herb may also be estrogenic, but what if it upregulates a receptor that helps create DHT.
RE: Botanicals that mimic or affect DHT, other dihydro-hormones, and 5α-reductase, - Dynseli - 15-07-2014
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?q=all&cid=8956#ec '20-alpha-Dihydroprogesterone' Pubchem compound
20-alpha-Dihydroprogesterone A.K.A. DIHYDROPROGESTERONE, Dihydrogesterone, 20alpha-Dihydroprogesterone, 20(S)-Hydroxyprogesterone, 20alpha-Progerol
"A biologically active 20-alpha-reduced metabolite of PROGESTERONE. It is converted from progesterone to 20-alpha-hydroxypregn-4-en-3-one by the 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE in the CORPUS LUTEUM and the PLACENTA."
5α-Dihydroprogesterone is another Dihydroprogesterone, that is a neurosteroid (produced in the brain). It is a PR agonist. https://en.wikipedia.org/wiki/5%CE%B1-Dihydroprogesterone
RE: Botanicals that mimic or affect DHT, other dihydro-hormones, and 5α-reductase, - Lotus - 15-07-2014
(15-07-2014, 06:33 AM)lovely11 Wrote: Red reishi and green tea reduce 5-alpha-reducatase thereby reducing DHT. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693613/table/tbl2680/?report=objectonly
Pygeum, saw palmetto, and nettle should be looked at to see if they reduce DHT. Verification is needed.
Daidzien is a phytochemical that is said to be estrogenic. but I believe it may act like DHT. A herb or phytochemical that increases body hair is suspect. A herb may also be estrogenic, but what if it upregulates a receptor that helps create DHT.
I had this in a draft in another thread, however I will list it here too.
Soy isoflavones have also been shown in several studies to elevate SHBG levels and to be mildly anti-estrogenic. High serum-High serum levels of estrogen also trick the brain into thinking that enough testosterone is being produced, further slowing its natural production. This happens when estrogen saturates testosterone receptors in the hypothalamus region of the brain. The saturated hypothalamus then stops sending out a hormone to the pituitary gland to stimulate secretion of luteinizing hormone that the gonads require to produce testosterone. High estrogen can thus shut down the normal testicular production of testosterone. A further complication of excess estrogen is that it increases the body's production of sex hormone-binding globulin (SHBG). SHBG binds free testosterone in the blood and makes it unavailable to cell receptor sites. The solution to this problem is to block the conversion of testosterone to estrogen.
By modulating androgen receptor coactivators, daidzein may act as a phytoandrogen
http://onlinelibrary.wiley.com/doi/10.1002/pros.20470/abstract;jsessionid=CB374D9A89B74EE19CA275F4FA69E7BF.f04t01
RE: Botanicals that mimic or affect DHT, other dihydro-hormones, and 5α-reductase, - Dynseli - 15-07-2014
[deleted] - moved to http://www.breastnexus.com/showthread.php?tid=21169&pid=124531#pid124531 - "Hormone binding; carrier proteins; (SHBG, albumin, CBG, transcortin)"
RE: Botanicals that mimic or affect DHT, other dihydro-hormones, and 5α-reductase, - Lotus - 15-07-2014
(15-07-2014, 09:24 PM)lovely11 Wrote:(15-07-2014, 08:58 PM)Lotus Wrote: High serum-High serum levels of estrogen also trick the brain into thinking that enough testosterone is being produced, further slowing its natural production. This happens when estrogen saturates testosterone receptors in the hypothalamus region of the brain. The saturated hypothalamus then stops sending out a hormone to the pituitary gland to stimulate secretion of luteinizing hormone that the gonads require to produce testosterone. High estrogen can thus shut down the normal testicular production of testosterone. A further complication of excess estrogen is that it increases the body's production of sex hormone-binding globulin (SHBG). SHBG binds free testosterone in the blood and makes it unavailable to cell receptor sites. The solution to this problem is to block the conversion of testosterone to estrogen.
This is why herbs that raise LH are useful. They seem to raise LH without causing negative feedback for androgen production. There might be negative feedback for LH production, but these can also be upregulated by herbs or by normal body functions. The adrenal glands also produce T. Androgen production just needs to be raised a few times, then it levels, that is enough to make estrogens. Testosterone doesn't need to keep being raised. Once its raised the body is already producing a level but higher level of testosterone. That is more than enough for conversion.
Estrogen dominance could already mean high T which both cause excess body hair, long and uncomfortable menstruation, tuberous breasts, etc... Here aromatase and raising LH are useful. What if prolactin and progestins raise AR sensitivity? Does estrogen shut down AR, does it upregulate it, or both? AR= androgen receptors
I've read that aromatase lowers prolactin in males (lacking), increased progesterone will cause an increase of prolactin. Increased estrogen levels can also stimulate increased prolactin levels. Prolactin stimulates the glandular tissue in the male breast. This is what causes the lactation and other gyno-like symptoms. The main control hormone for prolactin release is dopamine. Estrogens, and to a lesser extent progestins, can increase sensitivity of prolactin, but not necessarily increase levels.
Raising SHBG should up-regulate free T, which doesn't sound good for green tea at this point, I dunno, more searching I guess. The more exogenous testosterone that enters your body the more SHBG will be produced, its our own body's reaction or mechanism to maintain homeostasis. Definitely E shuts production of T down, which conventional thinking says that's what the mtf regime should be. Now the study I listed earlier from France says that enzymes play a role in raising E levels, and that's done through (not sure how much though) free T, or should we say bio-AVIABLE T.
RE: Botanicals that mimic or affect DHT, other dihydro-hormones, and 5α-reductase, - Dynseli - 15-07-2014
The text about SHBG belonged in the "Hormone binding; carrier proteins; (SHBG, albumin, CBG, transcortin)" thread. http://www.breastnexus.com/showthread.php?tid=21169
RE: Botanicals that mimic or affect DHT, other dihydro-hormones, and 5α-reductase, - Lotus - 15-07-2014
(15-07-2014, 10:06 PM)lovely11 Wrote: The text about SHBG belonged in the "Hormone binding; carrier proteins; (SHBG, albumin, CBG, transcortin)" thread. http://www.breastnexus.com/showthread.php?tid=21169
Which text?
RE: Botanicals that mimic or affect DHT, other dihydro-hormones, and 5α-reductase, - Dynseli - 15-07-2014
The text that's been copied over to http://www.breastnexus.com/showthread.php?tid=21169&pid=124531#pid124531 The text about daidzein belongs here, and hasn't been copied over. That thread is about SHBG and carrier proteins, This thread is about reductase, and dihydro-hormones including DHT.
RE: Botanicals that mimic or affect DHT, other dihydro-hormones, and 5α-reductase, - Lotus - 15-07-2014
(15-07-2014, 10:31 PM)lovely11 Wrote: The text that's been copied over to http://www.breastnexus.com/showthread.php?tid=21169&pid=124531#pid124531 The text about daidzein belongs here, and hasn't been copied over. That thread is about SHBG and carrier proteins, This thread is about reductase, and dihydro-hormones including DHT.
Ok, thanks.
RE: Botanicals that mimic or affect DHT, other dihydro-hormones, and 5α-reductase, - Dynseli - 22-07-2014
http://www.ncbi.nlm.nih.gov/pubmed/10930709 implies that Pygeum africanum, and Serenoa repens can lower 5-alpha reductase.
http://www.ncbi.nlm.nih.gov/pubmed/12006122 possibly beta-sitosterol