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spironolactone and licorice = synergistic combination?

#2

Nice find Abi:



Commentary: It’s very useful to find a second study on licorice and it’s role in PCOS. Glycyrrhetinic acid has been shown to reduce serum testosterone and induce regular ovulation. (Yaginuma T, Izumi R, Yasui H, et al. Effect of traditional herbal medicine on serum testosterone levels and its inductions of regular ovulation in hyperandrogenic and oligomenorrheic women. Nippon Sanka Fujinka Gakkai Zasshi 1982;34:939-944) ( Takahashi K, Yoshino K, Shirai T, et al. Effect of a traditional herbal medicine on testosterone secretion in patients with polycystic ovary syndrome detected by ultrasound. Nippon Sanka Fujinka Gakkai Zasshi 1988;789-92.)
Spironolactone is often used as part of a treatment plan in PCOS women with bothersome hirsutism. While Spironolactone can be helpful, fatigue and polyuria are a frequent side effect. It may be that licorice and glycyrrhetinic acid have a potential synergistic effect on the androgen receptors, reduce the side effects associated with Spironolactone, as well as reducing serum testosterone and inducing regular ovulation. Licorice extract along with a lower carbohydrate/higher protein diet, therapies that increase SHBG such as nettles root, green tea, flax seeds and soy and insulin sensitizing strategies such as daily aerobic exercise, fenugreek powder, cinnamon extract, d-pinitol, chromium (and possibly glucophage) offer a comprehensive approach for women with PCOS.
http://drtorihudson.com/botanicals/licor...-syndrome/

One other side effect from spiro is spasms. A few of us who use spiro have experienced these spasms. I get them on my sides, from what I've been able to find is its related to an electrolyte imbalance.

Quote:The mineralocorticoid antagonist, spironolactone, and its major circulating metabolite, canrenone, also competitively interact with adrenal steroid hydroxylases. In addition, spironolactone is converted by adrenal microsomes to an unknown metabolite which promotes the destruction of cytochromes P-450, decreasing the activities of steroid hydroxylases.
https://www.ncbi.nlm.nih.gov/m/pubmed/6786868/

Spiro inhibits DHT (by blocking androgen receptors)
@ 50%
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Messages In This Thread
spironolactone and licorice = synergistic combination? - by AbiDrew85 - 06-05-2016, 06:31 PM
RE: spironolactone and licorice = synergistic combination? - by Lotus - 06-05-2016, 07:27 PM
RE: spironolactone and licorice = synergistic combination? - by Lotus - 16-11-2016, 10:39 PM
RE: spironolactone and licorice = synergistic combination? - by ChangeofLife - 17-11-2016, 03:06 AM
RE: spironolactone and licorice = synergistic combination? - by Lotus - 17-11-2016, 04:33 AM
RE: spironolactone and licorice = synergistic combination? - by Skye is on fire - 17-11-2016, 12:45 PM
RE: spironolactone and licorice = synergistic combination? - by Lotus - 18-11-2016, 03:20 AM



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