[Lotus]

The mineralocorticoid antagonist, spironolactone, and its major circulating metabolite, canrenone, also competitively interact with adrenal steroid hydroxylases. In addition, spironolactone is converted by adrenal microsomes to an unknown metabolite which promotes the destruction of cytochromes P-450, decreasing the activities of steroid hydroxylases. 

i found this unknown metabolite of spironolactone: 

" 7α-thiospironolactone (SC-24813), a compound which is a potent mineralocorticoid antagonist and which promotes the destruction of adrenal and testicular cytochromes P-450. "

So this means spiro inhibits adrenal and testicular androgens (aka P-450 enzyme family), and I'll bet we'll be able to track it upstream of the CYP17A1 steriodogenisis pathway.