19-03-2018, 02:52 PM
(This post was last modified: 19-03-2018, 02:57 PM by tanysquirrel.)
https://ghr.nlm.nih.gov/gene/NR0B1
The NR0B1 gene provides instructions for making a protein called DAX1. This protein plays an important role in the development and function of several hormone-producing (endocrine) tissues in the body. These tissues include the small glands located on top of each kidney (the adrenal glands), two hormone-secreting glands in the brain (the hypothalamus and pituitary), and the gonads (ovaries in females and testes in males). Before birth, the DAX1 protein helps regulate genes that direct the formation of these tissues. DAX1 also helps regulate hormone production in endocrine tissues after they have been formed.
Since it (DAX1), is found both in ovaries AND testes, I do not think it is specifically DAX1 that would be the "switch" to flipping the genes from male to female. It is also found on the adrenal glands.. so that furthers my thoughts the FOXL2 gene is more in control than what I thought the DAX1 would do.
The NR0B1 gene provides instructions for making a protein called DAX1. This protein plays an important role in the development and function of several hormone-producing (endocrine) tissues in the body. These tissues include the small glands located on top of each kidney (the adrenal glands), two hormone-secreting glands in the brain (the hypothalamus and pituitary), and the gonads (ovaries in females and testes in males). Before birth, the DAX1 protein helps regulate genes that direct the formation of these tissues. DAX1 also helps regulate hormone production in endocrine tissues after they have been formed.
Since it (DAX1), is found both in ovaries AND testes, I do not think it is specifically DAX1 that would be the "switch" to flipping the genes from male to female. It is also found on the adrenal glands.. so that furthers my thoughts the FOXL2 gene is more in control than what I thought the DAX1 would do.