[tanysquirrel]

BHT -

http://www.ncbi.nlm.nih.gov/pubmed/6343068
Abstract

Although the average American's daily consumption of BHT can be measured in milligrams, there are numerous reports that BHT causes organ damage in laboratory animals. Only a few genotoxic effects of BHT have been reported, however, including mutagenicity in the abnormal sperm assay and ambiguous results regarding its teratogenicity. More dramatic are the modulatory effects of BHT on the actions of established mutagens and carcinogens. BHT can either enhance or inhibit mutagenic potency, depending on the substance tested. For example, in the Ames test, BHT is antimutagenic towards benzo(a)pyrene, but increases the number of Salmonella revertants induced by aflatoxin B1. BHT is one of the few compounds to have both tumor prophylactic and tumor promoting capacities. It is the temporal sequence in which BHT and carcinogens are administered to test animals which determines how BHT affects the response to these carcinogens. In common with other antioxidants, BHT inhibits the ability of carcinogens to induce tumors in various rodent organs when the animal is given BHT prior to carcinogen treatment. Unlike other antioxidants, however, the number of tumors increase when BHT is administered after carcinogen exposure. The comutagenic and cocarcinogenic properties of BHT have been demonstrated in tests ranging from the Ames test to cell transformation procedures to in vivo assays. These effects are probably mediated by metabolites of BHT, rather than by BHT itself

caution should be used with this, if you have pre-existing tumors/cancer

it is lipophilic :
http://cancerres.aacrjournals.org/conten.../558.short
Abstract

The effects of hydrogenated fats and butylated hydroxytoluene (BHT) in the diets of rats on the hepatic activation of benzo(a)pyrene, 2-acetylaminofluorene (AAF), and 2-aminofluorene by liver homogenates (S-9 fraction) were evaluated. The Salmonella/microsomal mutagenicity assay (Strain TA 98) was utilized to determine the mutagenic potential of the activated compounds. The S-9 fraction was obtained from animals fed a 15% fat diet consisting of hydrogenated fats (43% trans-fatty acids) or unsaturated fats (0% trans-fatty acids). BHT was administered orally (0.5%) 6 days prior to sacrifice in both groups.

The incorporation of BHT in the diet of rats enhanced the mutagenic potential of AAF and 2-aminofluorene but not of benzo(a)pyrene. This effect was independent of the lipid composition of the diet. The most significant increment in the production of mutagenic metabolites was observed with AAF when BHT and hydrogenated fats were included in the diet of rats. Dietary hydrogenated fats appeared to potentiate the effects of BHT on AAF mutagenicity. Further studies to elucidate the mechanisms by which BHT and hydrogenated fats enhance AAF mutagenicity are warranted

used as an anti-viral (one person's testimonial):
http://www.democraticunderground.com/discuss/duboard.php?az=view_all&address=105x1132937
My investigations and self experimentation with the compound commonly referred to as BHT, or butylated hydroxytoluene ,as a treatment for hepatitis C began in 1997, as a result of reading DURK PEARSON and SANDY SHAW`S: THE LIFE EXTENSION COMPANION. I wish to state first of all that they recommend people with liver disease SHOULD NOT USE BHT. They discuss it as a treatment for HERPES types 1 and 2. As far as I know the original discoverers of BHT AS A TREATMENT for viral diseases are: Snipes, Person, Keith, and Cupp. These scientists have had their works published in numerous journals over time. Anyway, as a result of many blood transfusions < 17 units > in 1968 I contracted hepatitis C and B. I became very ill with HEP C in 1997. I felt what have I got to lose and started taking 250 mg caps of BHT 3- 4 TIMES a week to see if it would help me. It helped me a lot and I continue using it as a treatment to this day. There have been numerous papers written as to BHT`s effectiveness as a treatment for a broad range of viral diseases including AIDS, in America and other Nations.Many published in respectable publications. I have written my own thoughts on exactly how BHT readily destroys perhaps all viruses in inter cellular fluids such as blood. Simply stated ,my thoughts are that compounds such as BHT , being hydrophobic are drawn to and accumulate in structures such as viruses and generate free radical and ionic reactions inter cellularly that rapidly destroy viruses and other substances such as vascular deposits and the harmful tars that damage smokers lungs. The specifics of my reasoning would take a short book to explain. Exactly how and why these chemical reactions take place and how the cells are able terminate these reactions. I would have to do extensive referencing and such and do not feel like it right now. DIG UP BOOKS AND CREDIT AUTHORS AND SUCH. Anyway, I do believe BHT is an effective treatment for hepatitis C and many other viral diseases. "

if accurate, it is not a totally bad thing, i would definitely make sure the conditions are right before use (such as making sure you do not have pre-existing tumors/cancer)

[tanysquirrel]

Atrazine- Continued
http://europepmc.org/articles/PMC3774316
Component: (DACT) diaminochlorotriazine
effect : The primary metabolite of the herbicide atrazine (ATRA), diaminochlorotriazine (DACT), has been suggested to cause disruption in the hypothalamic-pituitary-gonadal axis leading to inhibition of luteinizing hormone (LH) release.

http://www.ncbi.nlm.nih.gov/pubmed/19690231
Abstract

Previously, we reported that atrazine (ATR) alters steroidogenesis in male Wistar rats resulting in elevated serum corticosterone (CORT), progesterone, and estrogens. The increase in CORT indicated that this chlorotriazine herbicide may alter the hypothalamic-pituitary-adrenal axis. This study characterizes the temporal changes in adrenocorticotropic hormone (ACTH), CORT, and P4 in male Wistar rats following a single dose of ATR (0, 5, 50, 100, and 200 mg/kg), simazine (SIM; 188 mg/kg), propazine (PRO; 213 mg/kg), or primary metabolites, deisopropylatrazine (DIA; 4, 10, 40, 80, and 160 mg/kg), deethylatrazine (DEA; 173 mg/kg), and diamino-s-chlorotriazine (DACT; 3.37, 33.7, 67.5, and 135 mg/kg). The maximum dose for each chemical was the molar equivalent of ATR (200 mg/kg). Significant increases in plasma ACTH were observed within 15 min, following exposure to ATR, SIM, PRO, DIA, or DEA. Dose-dependent elevations in CORT and progesterone were also observed at 15 and 30 min post-dosing with these compounds indicating an activation of adrenal steroidogenesis. Measurement of the plasma concentrations of the parent compounds and metabolites confirmed that ATR, SIM, and PRO are rapidly metabolized to DACT. Although DACT had only minimal effects on ACTH and steroid release, dosing with this metabolite resulted in plasma DACT concentrations that were 60-fold greater than that observed following an equimolar dose of ATR and eightfold greater than equimolar doses of DIA or DEA, indicating that DACT is not likely the primary inducer of ACTH release. Thus, the rapid release of ACTH and subsequent activation of adrenal steroidogenesis following a single exposure to ATR, SIM, PRO, DIA, or DEA may reflect chlorotriazine-induced changes at the level of the brain and/or pituitary


so, this is not only quick acting, it only takes one dose to start the metabolic changes, it seems

https://www.researchgate.net/publication..._cell_line

[tanysquirrel]

Diosgenin
https://en.wikipedia.org/wiki/Diosgenin

Diosgenin, a steroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam, such as the Kokoro. The sugar-free (aglycone), diosgenin is used for the commercial synthesis of cortisone, pregnenolone, progesterone, and other steroid products.
Clinical uses[edit]

Diosgenin is the precursor for the semisynthesis of progesterone[3] which in turn was used in early combined oral contraceptive pills.[4] The unmodified steroid has estrogenic activity[5] and can reduce the level of serum cholesterol.[6]

Diosgenin may behave as a prodrug to progesterone.[7][8]
https://en.wikipedia.org/wiki/Prodrug
prodrug: A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.[1][2] Inactive prodrugs are pharmacologically inactive medications that are metabolized into an active form within the body. Instead of administering a drug directly, a prodrug might be used instead to improve how a medicine is absorbed, distributed, metabolized, and excreted (ADME).[3][4] Prodrugs are often designed to improve bioavailability when a drug itself is poorly absorbed from the gastrointestinal tract.[1] A prodrug may be used to improve how selectively the drug interacts with cells or processes that are not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects.

[tanysquirrel]

interesting:

http://www.ncbi.nlm.nih.gov/pubmed/27061936
Synergistic Effects of Potentilla fruticosa L. Leaves Combined with Green Tea Polyphenols in a Variety of Oxidation Systems

Abstract

Potentilla fruticosa L. leaves are widely used as tea in China, with many commercial "Jinlaomei" teas available in markets. It has been confirmed to possess significant antioxidant activity than that of butylated hydroxytoluene. In this study, the synergistic effects of P. fruticosa leaves extracts (PFE) combined with green tea polyphenols (GTP) were studied to elucidate their use in combination and find specific combinations with least concentrations that enhance the antioxidant activity. Isobolographic analysis indicated that the combination of PFE and GTP demonstrated extensive synergism (22/28 of the tests showed significant synergy) with 3:1 (PFE:GTP) exhibiting the best synergistic effect. Chemical compositions and content of 7 phenolic compounds in PFE, GTP, and their mixtures were evaluated by reverse-phase-high-performance liquid chromatography. While chemical composition did not seem to change after the combination, as no new peaks appeared in the chromatogram, and no existing peaks disappeared. However, the content of (+)-catechin, (-)-epigallocatechin (EGC), and , (-)-epigallocatechin gallate (EGCG) changed. Besides, antioxidant interactions of extracts and compounds were evaluated, EGC with hyperoside exhibited the greatest synergistic effect and the combination of 3:1 exhibited the strongest synergism (DPPH γ = 0.86, ABTS γ = 1.12, FRAP γ = 1.16). Therefore, interaction of phytochemicals may be one reason for the synergistic effects in PFE + GTP, with EGC + hyperoside likely playing an important role. This report provides a theoretical basis for the concomitant use of P. fruticosa blended with GTP, which can be effectively used as a compounded tea, dietary supplements, and substituent of synthetic antioxidant

[tanysquirrel]

Moringa oleifera

what it is:
https://en.wikipedia.org/wiki/Moringa_oleifera
Moringa oleifera is the most widely cultivated species of the genus Moringa, which is the only genus in the family Moringaceae. English common names include: moringa,[2] drumstick tree[2] (from the appearance of the long, slender, triangular seed-pods), horseradish tree[2] (from the taste of the roots, which resembles horseradish), ben oil tree, or benzoil tree[2] (from the oil which is derived from the seeds). It is a fast-growing, drought-resistant tree, native to the southern foothills of the Himalayas in northwestern India, and widely cultivated in tropical and subtropical areas where its young seed pods and leaves are used as vegetables. It can also be used for water purification and hand washing, and is sometimes used in herbal medicine.[3]

The leaves are the most nutritious part of the plant, being a significant source of B vitamins, vitamin C, provitamin A as beta-carotene, vitamin K, manganese, and protein, among other essential nutrients.[3][20][21] When compared with common foods particularly high in certain nutrients per 100 g fresh weight, cooked moringa leaves are considerable sources of these same nutrients. Some of the calcium in moringa leaves is bound as crystals of calcium oxalate[22] though at levels 1/25th to 1/45th of that found in spinach, which is a negligible amount.

The leaves are cooked and used like spinach and are commonly dried and crushed into a powder used in soups and sauces.

Drumsticks[edit]





Drumstick vegetable pods at a market
The immature seed pods, called "drumsticks", are commonly consumed in South Asia. They are prepared by parboiling, and cooked in a curry until soft.[23] The seed pods/fruits, even when cooked by boiling, remain particularly high in vitamin C[24] (which may be degraded variably by cooking) and are also a good source of dietary fiber, potassium, magnesium, and manganese.[24]



role: lactation enhancer/ovarian cancer cure/protein source

http://www.organicvedamoringa.com/moringa-for-lactation

http://www.naturalnews.com/034976_moring...betes.html

http://www.smallruminantresearch.com/art...2/abstract


available for $20.99/400mg 120 caps (prime shipping) on Amazon.

[tanysquirrel]

Caralluma Fimbriata

sold as a weight loss and appetite suppression it also contains:

The key phytochemical constituents of the herb are pregnane glycosides, flavone glycosides, megastigmane glycosides, and saponins.[citation needed] active constituents- caratuberoside I-X,tomentogenin, silolsterol, luteolin-4-neohesperidoside and kaemferol-7-0- neohesperidoside.

pregnane regnane is, indirectly, a parent of progesterone. It is a parent hydrocarbon for two series of steroids stemming from 5α-pregnane (originally allopregnane) and 5β-pregnane (17β-ethyletiocholane).

5β-Pregnane is the parent of the progesterones, pregnane alcohols, ketones, and several adrenocortical hormones and is found largely in urine as a metabolic product of 5β-pregnane compounds.

it is available on Amazon for around 17 dollars/bottle

so if that is the case, will it increase/promote increased progesterone conversion? More research needed

[tanysquirrel]

interesting:


http://www.nordesthetics.com/en/articles...necomastia
How is protein powder related to gynecomastia?

Casein and whey protein are extracted from cow milk. According to the Harvard Gazette, in modern farms cows are milked several hundred times a year. Inevitably, for much of that time cows are pregnant. During pregnancy cow endocrine system produces estrogen and this hormone gets into the milk. Milk from a cow which is in the late stage of pregnancy contains approximately 33 times more estrogen than milk from a cow which is not pregnant. There is a hypothesis suggesting that casein and whey protein powder contains estrogen and may cause gynecomastia. However, there is other opinion that estrogen levels in protein powder are too low to have physiological effect on human body. All in all, casein and whey protein powder may be related to gynecomastia but it depends on many circumstances including age and hormonal sensitivity.


anecdotal evidence:
http://www.elitefitness.com/forum/diet-b...95194.html
more research needed.

[tanysquirrel]

pine pollen is androgenic??? ..who knew?

https://supermanherbs.com/estrogens-vs-androgens/

Many people in the field of health are aware of these. But most are not aware of phyto-androgens. Part of this reason is that these are far more rare.

Luckily there is one substance that is fully loaded with them, the pollen of pine trees. (As a side note, pine nuts do contain some androgens, but in much smaller amounts.)

Pine Pollen Release
As part of the reproduction of pine trees, pine pollen is loaded with phyto-androgens which the human body can benefit from.

Pine pollen, as the male reproductive part of a pine tree, has many phyto-androgens.

Pine pollen contains gibberellins which are structurally very similar to testosterone. In fact, they have been found to actually connect with testosterone receptors in the human body. Basically, they can mimic testosterone in the body and, as Stephan Harrold Buhner tells us in his book The Natural Testosterone Plan, “because of their adrenal and pituitary actions, they stimulate androgen production in the body; energy levels increase.” They act as prostate regulators, up­regulating when the prostate is too small (one study had castrated rats keep their prostates from shrinking) and down­ regulate when the prostate is too big and inflamed. They are also anti­cancerous and anti­-inflammatory in the rest of the body.

Pine pollen also contains over 30 different kinds of brassinosteroids. Two of these brassinosteroids are used in the mechanism through which the liver safely removes xenoestrogens and other chemicals from the body. They have strong anti­viral actions and are, “considered to be highly novel steroidal compounds with unique anticancer actions while possessing very low toxicity.”

Pine pollen has substances that are similar to testosterone, DHEA, androstenedione, androsterone and more. And that’s not all. Its chock full of nutrition with over 200 bioactive antioxidants, vitamins, minerals, amino acids and other super nutrients.

Understand that this is not like hormone replacement therapy. These are small amounts of hormones, but combined with the intelligence of all the necessary co-factors found in pine pollen. This doesn’t boost your hormones to unsafe levels, but instead helps to educate your body towards a more normal or optimized function.


best to avoid for those transitioning (hard to avoid during spring though)...

[tanysquirrel]

Cimitidine Continued:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1419438/

Gynaecomastia has occurred unilaterally or bilaterally in five out of 25 male duodenal ulcer patients after more than four months treatment with cimetidine 1.6 g daily. All elected to continue treatment to 12 months and their breast enlargement regressed rapidly and disappeared after stopping treatment. During treatment all patients were found to have normal concentrations of plasma testosterone and oestradiol, and serum prolactin was normal in the two patients measured. Excision biopsy of the subareolar tissue in one patient revealed histology typical of the florid stage of gynaecomastia. Blockade of androgen-responsive receptors receptors in the target organ appears to be the most likely mechanism involved

I wonder if topically used , it would dramatically induce gynecomastia...

[tanysquirrel]

for those transitioning (MTF)

a few handy guides for the beginners

Shoe size conversion (Male to female size, uk AND Us available, use drop downs to change).
http://www.csgnetwork.com/shoe_size_converter.html

Clothing size conversion (Male to female size)
http://www.lauras-playground.com/legacy/size_chart.htm
Waist: Remember that female waists are 3 inches higher than mens.