30-09-2012, 05:35 AM
Haha. tibetan just asked that same question and I just answered it in her thread! But I'm happy to repeat it here.
I don't KNOW that as fact. There hasn't been anywhere near enough studies done on BO to say ANYTHING about it as fact. Other than that it's estrogenic, progestogenic, and mildly androgenic. But we can't factually KNOW for certain which receptors it's hitting more strongly.
I'm basing this more on extrapolation based on studies done on premarin. Which are horse estrogens conjugated from their urine. These studies did find that horse estrogens bind more strongly to alpha receptors than beta's, and even more strongly than natural human estradiol. They also indicated that they all but ignored the beta's.
Since BO is also animal source, and not human, I figure it'll likely be similar even though there are no studies to point to and prove it. Since human estradiol itself also tends to favor the alpha's and only go after the beta's if there's nothing else binding to them, I'd say there's a pretty strong pattern there.
Is it proof positive? Nope. And nor am I at all equipped to perform an adequate study to prove it. I think it'd be really interesting if one of the more expensive BO suppliers performed such a study though. Or someone else concerned the old Premarin scares could repeat themselves.
I don't KNOW that as fact. There hasn't been anywhere near enough studies done on BO to say ANYTHING about it as fact. Other than that it's estrogenic, progestogenic, and mildly androgenic. But we can't factually KNOW for certain which receptors it's hitting more strongly.
I'm basing this more on extrapolation based on studies done on premarin. Which are horse estrogens conjugated from their urine. These studies did find that horse estrogens bind more strongly to alpha receptors than beta's, and even more strongly than natural human estradiol. They also indicated that they all but ignored the beta's.
Since BO is also animal source, and not human, I figure it'll likely be similar even though there are no studies to point to and prove it. Since human estradiol itself also tends to favor the alpha's and only go after the beta's if there's nothing else binding to them, I'd say there's a pretty strong pattern there.
Is it proof positive? Nope. And nor am I at all equipped to perform an adequate study to prove it. I think it'd be really interesting if one of the more expensive BO suppliers performed such a study though. Or someone else concerned the old Premarin scares could repeat themselves.