30-09-2012, 06:28 AM
OH! And in case any one is curious what I'm referring to by the "old premarin scares"...
One of the things those studies were concerned about was why did it seem that there was an increased rate of occurrence of feminine cancers in women who were on premarin for hrt?
What they wound up discovering was that premarin was EXTREMELY aggressive for alpha receptors, literally forcing what estradiol the women were still producing onto the beta's. Since these women were older and therefore had much much larger receptor counts and their receptors were already damaged by age, when the estradiol flooded their beta's it quite literally took already damaged tissue and inflamed it like no tomorrow. This inflammation directly led to the increased risk of cancer.
So, I would actually quite honestly suggest most women steer clear of excessive BO doses UNLESS they also take phyto's to keep the estradiol off those beta's. Especially as they get older. The risks aren't as severe in younger women. After all, every teen girl experiences a flood during early puberty and most never get cancer at that age.
But as you get older, and your cancer risk rises... It is my honest opinion that animal source estrogens are best left alone in natal females.
Of course, if my extrapolation of the pattern is completely wrong, then there's nothing to worry about... but since there aren't any conclusive studies either way, and there ARE conclusive studies done on premarin... Isn't it better safe than sorry?
One of the things those studies were concerned about was why did it seem that there was an increased rate of occurrence of feminine cancers in women who were on premarin for hrt?
What they wound up discovering was that premarin was EXTREMELY aggressive for alpha receptors, literally forcing what estradiol the women were still producing onto the beta's. Since these women were older and therefore had much much larger receptor counts and their receptors were already damaged by age, when the estradiol flooded their beta's it quite literally took already damaged tissue and inflamed it like no tomorrow. This inflammation directly led to the increased risk of cancer.
So, I would actually quite honestly suggest most women steer clear of excessive BO doses UNLESS they also take phyto's to keep the estradiol off those beta's. Especially as they get older. The risks aren't as severe in younger women. After all, every teen girl experiences a flood during early puberty and most never get cancer at that age.
But as you get older, and your cancer risk rises... It is my honest opinion that animal source estrogens are best left alone in natal females.
Of course, if my extrapolation of the pattern is completely wrong, then there's nothing to worry about... but since there aren't any conclusive studies either way, and there ARE conclusive studies done on premarin... Isn't it better safe than sorry?