(01-02-2017, 05:04 AM)BeautifulBambi Wrote: Any opinions on Swanson White Peony Root will it work just fine?
Someone shared the WP content of Swanson's brand a while back (my apologies to the OP I don't remember who though). White peony (standardized) should bump aromatase 2-3 fold (based on scientific literature) a 30% increase, for myself that means an increase of 60-80 pg/mL blood estradiol, though everybody is different. I believe Life Extension sells a standardized capsule but Swanson full spectrum isn't standardized.
(15-12-2016, 10:57 PM)Stevenator Wrote: It's Swanson's capsules.
I'll have to check the label.
I believe it's not standardized (lol, I have a bottle sitting on the shelf too). Here's a few things about WP, or where I think the rubber needs to meet the road, or more to the point finding a suitable WP supplement that contains two compounds: 6'-O-galloylalbiflorin and pentagalloylglucos, they bind androgen receptors and inhibit DHT. Let's let science solve this puzzle of what WP does for NBE.....which I think we just did. The dose could be less than I calculated earlier if these compound and the main glycoside 3'-O-galloylpaeoniflorin are present would be estimated at 1 gram.
Additionally, testosterone/delta 4-androstenedione production ratio is also reduced (significantly) by paeoniflorin (white peony).
(26-01-2016, 09:26 PM)Lotus Wrote: So, in ovaries WP promotes aromatase, (I believe in the breasts too), inhibits DHT in sebum, inhibits prostate cancer cells, (which means it inhibits C17 @ CYP17 P450 enzyme, a strong anti-androgen. The lab dosage was 2 grams (I'll have to double check). Roots be king.
Androgen modulators from the roots of Paeonia lactiflora (paeoniae radix) grown and processed in nara prefecture, Japan.
Washida K1, Itoh Y, Iwashita T, Nomoto K.
The monoterpene glycoside, 3'-O-galloylpaeoniflorin (1), and four known compounds, 6'-O-galloylalbiflorin (2), pentagalloylglucose (3), 6'-O-benzoylpaeoniflorin (4) and 6'-O-galloylpaeoniflorin (5), were isolated from the roots of Paeonia lactiflora that had been grown and processed in Nara prefecture, Japan, as androgen modulators. Their structures were elucidated based on spectroscopic analysis. Compounds 2 and 3 showed strong androgen receptor (AR) binding activity (IC(50) values 33.7 and 4.1 microg/ml, respectively), 1, 4 and 5 showed weak activity (20, 31 and 12% at 120 microg/ml, respectively). However, paeoniflorin (6) and albiflorin (7), the structures of which are related to 1, 2, 4 and 5, showed no activity. These results suggested that both the structure of albiflorin and the galloyl moiety are important for 2 to show strong AR binding activity. Furthermore, compounds 1-5 inhibited growth of an androgen-dependent LNCaP-FGC (prostate cancer cell line), and were indicated to be AR antagonists. Compounds 2 and 3 might be candidates as safe, natural anti-androgens.
Testosterone/delta 4-androstenedione production ratio was lowered significantly by paeoniflorin, and two compounds, 6'-O-galloylalbiflorin and pentagalloylglucos bind androgen receptors and inhibit DHT.