(21-02-2014, 02:49 PM)lostacres6 Wrote: Can you please clarify: Shatavarins block Oxycotin - is this a good thing? Does Oxycotin have a role in NBE?
Reported as safe, I thought the statement concerning LD50 will reinforce it. I actually found a recent study (found below) Herbal compositions improving lactation of farmed livestock, that shatavarins (Asparagus racemosus) was used by improving milk release. The effect worked on the central nervous systems putting the livestock at ease thereby releasing the flow of milk. Oh yeah, I had know idea how over stressed livestock get and prevent milk flow and that their calfs don't survive because of it.
Anyways back to Oxytocin, what the main reason to use shatavari- because of its
Galactagogue, and Oxytocin is also used in veterinary medicine to facilitate birth and to stimulate milk release. It took awhile to find, but the statement blocking oxytocin is in reference to in-Vivo
blocked oxytocin induced contractions, nothing in detail. (So for that reason I'll delete that statement)
Oxytocin plays a role in breast development during pregnancy. Like prolactin, oxytocin is secreted by the pituitary gland within the brain. According to Robert Wood Johnson University Hospital, oxytocin levels are high during the fifth and sixth months of pregnancy, and oxytocin helps stimulate milk production within the breast. The University of California reports that oxytocin also signals to the breast following childbirth to signal lactation in breastfeeding. http://www.livestrong.com/article/107569...velopment/
But yeah Oxytocin has a role in NBE, imo, I could do a separate thread dedicated to the variables of Oxytocin if you'd like.
In Ayurveda, A. racemosus has been described as absolutely safe for long term use, even during pregnancy and lactation. Systemic administration of higher doses of all the extracts did not produce any abnormality in behaviour pattern of mice and rat. LD of the product lactare has not been assessed since it did not produce mortality even upto the oral dosages of 64 gm/kg.
This is where the information was obtained
Shatavarins (containing Shatavarin IV) with anticancer activity from the roots of Asparagus racemosus.