DHT is public enemy number one for boob growth, roughly 98% of Total T is not active, and out of that 2% is what's considered Free T (bio-active). Once Free T is converted to DHT it can't convert back to Free T.
We also know that too much E turns off those receptors and feedback is locked, so what to do?.
Well you have to think in terms of reactivating those receptors, you know!!, clear them out to start the process over,
Question- what's the half life of E (not miroestriol)...does anybody get where this is going?.
I have often wondered the same thing! I think its crucial to metabolize these active hormones efficiently or they will build up in the liver much sooner than they normally do, causing the receptors to shut down/ feedback loop effect. For ex, as much as DIM is apart of men's formulas and women's to rid E excess, I think the most important part of what we need from it is actually being able to use these hormones as they flush out of the system. The liver is so important in nbe and metabolizing hormones. The abundance of free running hormones in the blood can be from poor liver function.
I think that is why the Cycling of "hormones" format is so important. It creates the re sensitivity factor consistently. I'm starting to think this is why plateaus happen after a while, loaded receptors and acute poor functioning of the liver.
This totally explained why my first attempt in nbe went detrimental. I had blood tests confirm free high estrogen and testosterone ( from high DHEA) and progesterone (though lowest of them all). And of course, I got some serious androgen conversion. I had no nbe success at all and the worst bumpy skin after months of taking all sorts of herbs (mainly estrogenic).So one can have high levels of E hormones and have no breast developmental effects at all, yet have mild masculating effects . I sadly developed some nice little stray hairs on my areola that were never there before
They were gone thankfully after cleansing
Im convinced, that DHT is the little devil that breaks nbe success. I would personally like to raise my T levels as I am naturally low, but I am so sensitive to DHT conversion from my wonky adrenals.