[Lotus]

So is this surprising that the PM extract High 120:1 Potency can be used as follows:


1) Adding to your favorite non-alcohol drink (grapefruit juice for me)

Lotus - How do you stop the grapefruit juice from messing up the effects of all the other things you take? I really like GJ but have to avoid it because of its unpredictable effects. Have you noticed a difference between white and pink GJ?

BTW,, since stopping the gabapentin the swelling and edema in my legs has gone and I have lost again the 14 lbs I had gained

Hi Annie,

Grapefruit juice blocks the action of specific enzymes needed to absorb and break down drugs. These enzymes, found in the intestinal wall and liver, are called cytochrome P-450 3A4 and 1A2 (CYP3A4 and CYP1A2, for short). Several constituents of grapefruit juice have been implicated, including specific flavonoids and other phytochemicals called furanocoumarins.

By inhibiting the action of these enzymes, grapefruit juice increases your body’s absorption of certain drugs, and also slows the process of breaking them down in the liver. Thus certain drugs affected by these enzymes stay in the body longer than normal.
http://www.pkdiet.com/pages/herbs/food/grapefruit.htm

As you know PABA slows the breakdown estrogen by the same action. I've been using white GFJ with no sugar added and for the most part it eliminates the sour extract taste. Checkout the thread below if ya get a chance, it goes a bit deeper in absorption details and enzymes.

FAQ-Absorption rates
http://www.breastnexus.com/showthread.php?tid=19863


That's awesome news about the weight, I guess it just goes to show how one drug can have such an opposite effect of it's intended benefit.

Just some caution using Grapefruit Juice, Grapefruit juice and fresh grape-
fruit can interfere with the action of some prescription meds, please check the link below to be safe.


Grapefruit Juice and Medicine May Not Mix
http://www.fda.gov/downloads/ForConsumer...292839.pdf

[AnnieBL]

So is this surprising that the PM extract High 120:1 Potency can be used as follows:


1) Adding to your favorite non-alcohol drink (grapefruit juice for me)

Lotus - How do you stop the grapefruit juice from messing up the effects of all the other things you take? I really like GJ but have to avoid it because of its unpredictable effects. Have you noticed a difference between white and pink GJ?

BTW,, since stopping the gabapentin the swelling and edema in my legs has gone and I have lost again the 14 lbs I had gained

Hi Annie,

Grapefruit juice blocks the action of specific enzymes needed to absorb and break down drugs. These enzymes, found in the intestinal wall and liver, are called cytochrome P-450 3A4 and 1A2 (CYP3A4 and CYP1A2, for short). Several constituents of grapefruit juice have been implicated, including specific flavonoids and other phytochemicals called furanocoumarins.

By inhibiting the action of these enzymes, grapefruit juice increases your body’s absorption of certain drugs, and also slows the process of breaking them down in the liver. Thus certain drugs affected by these enzymes stay in the body longer than normal.
http://www.pkdiet.com/pages/herbs/food/grapefruit.htm

As you know PABA slows the breakdown estrogen by the same action. I've been using white GFJ with no sugar added and for the most part it eliminates the sour extract taste. Checkout the thread below if ya get a chance, it goes a bit deeper in absorption details and enzymes.

FAQ-Absorption rates
http://www.breastnexus.com/showthread.php?tid=19863


That's awesome news about the weight, I guess it just goes to show how one drug can have such an opposite effect of it's intended benefit.

Just some caution using Grapefruit Juice, Grapefruit juice and fresh grape-
fruit can interfere with the action of some prescription meds, please check the link below to be safe.


Grapefruit Juice and Medicine May Not Mix
http://www.fda.gov/downloads/ForConsumer...292839.pdf

Thank you for making me revisit the grapefruit juice issue. Since I am on warfarin and subject to regular INR tests, it has almost been an article of faith that grapefruit juice is not consistent with well controlled INR and may push it too high. Having read or reread your references, and a number more as well, it does seem that grapefruit juice in moderate quantities should not present a problem. Somewhat to my surprise, it looks as if cranberry juice may present at least as much of a problem (I have in recent months been taking a lot of cranberry juice to help control urinary tract infections). There do appear to be various reported cases in which both juices have been linked with dangerously or even lethally high INR readings, but these all seem to have involved very large juice intakes and probably other factors. Controlled trials with moderate intakes seem to suggest that they should not present a problem. I celebrated by going out and buying grapefruit.

[Lotus]

So is this surprising that the PM extract High 120:1 Potency can be used as follows:


1) Adding to your favorite non-alcohol drink (grapefruit juice for me)

Lotus - How do you stop the grapefruit juice from messing up the effects of all the other things you take? I really like GJ but have to avoid it because of its unpredictable effects. Have you noticed a difference between white and pink GJ?

BTW,, since stopping the gabapentin the swelling and edema in my legs has gone and I have lost again the 14 lbs I had gained

Hi Annie,

Grapefruit juice blocks the action of specific enzymes needed to absorb and break down drugs. These enzymes, found in the intestinal wall and liver, are called cytochrome P-450 3A4 and 1A2 (CYP3A4 and CYP1A2, for short). Several constituents of grapefruit juice have been implicated, including specific flavonoids and other phytochemicals called furanocoumarins.

By inhibiting the action of these enzymes, grapefruit juice increases your body’s absorption of certain drugs, and also slows the process of breaking them down in the liver. Thus certain drugs affected by these enzymes stay in the body longer than normal.
http://www.pkdiet.com/pages/herbs/food/grapefruit.htm

As you know PABA slows the breakdown estrogen by the same action. I've been using white GFJ with no sugar added and for the most part it eliminates the sour extract taste. Checkout the thread below if ya get a chance, it goes a bit deeper in absorption details and enzymes.

FAQ-Absorption rates
http://www.breastnexus.com/showthread.php?tid=19863


That's awesome news about the weight, I guess it just goes to show how one drug can have such an opposite effect of it's intended benefit.

Just some caution using Grapefruit Juice, Grapefruit juice and fresh grape-
fruit can interfere with the action of some prescription meds, please check the link below to be safe.


Grapefruit Juice and Medicine May Not Mix
http://www.fda.gov/downloads/ForConsumer...292839.pdf

Thank you for making me revisit the grapefruit juice issue. Since I am on warfarin and subject to regular INR tests, it has almost been an article of faith that grapefruit juice is not consistent with well controlled INR and may push it too high. Having read or reread your references, and a number more as well, it does seem that grapefruit juice in moderate quantities should not present a problem. Somewhat to my surprise, it looks as if cranberry juice may present at least as much of a problem (I have in recent months been taking a lot of cranberry juice to help control urinary tract infections). There do appear to be various reported cases in which both juices have been linked with dangerously or even lethally high INR readings, but these all seem to have involved very large juice intakes and probably other factors. Controlled trials with moderate intakes seem to suggest that they should not present a problem. I celebrated by going out and buying grapefruit.

I'm so happy for you Annie that a celebratory grapefruit is in order, odd that it has such a effect on metabolism though. Did you see the statement about Seville oranges (marmalade) has the same effect?. I had know idea about cranberry juice, thanks!.

[AnnieBL]

I'm so happy for you Annie that a celebratory grapefruit is in order, odd that it has such a effect on metabolism though. Did you see the statement about Seville oranges (marmalade) has the same effect?. I had know idea about cranberry juice, thanks!.

Yes, I saw that bit about Seville oranges. Worrying, because Seville orange marmalade is an important part of my cultural background. I think it also implicated Mineolas, a favourite of my wife's. Also I am myself very keen on pomelos which are closely related to grapefruit. The US originating pink pomelos in particular may I think in fact pomelo/pink grapefruit crosses. Somewhere else I saw the problem broadened to citrus fruit in general, but there are contrary statements that orange juice has no effect. Perhaps the lesson is 'moderation in all things'. A few years back I used to swill large amounts of OJ first thing in the morning under the impression it was 'healthy' and I think it was responsible for making me prediabetic for a time and thus together with CVI for my peripheral neuropathy. I treat it and other concentrated sources of rapidly assimilable carbs with much more restraint these days, and avoid it and them first thing or on its own or at the beginning of a meal. I'm a convert to trying to avoid excessive glycemic loads. Not directly on topic I know, but bad dietary habits can't be helpful in NBE.

Thanks again - keep well!

[EvaMarie]

A particular concern of mine is to minimize the risk of prostate cancer, as both my father and grandfather died of it. I have episodically taken DIMM thinking it might help, but grew concerned that it might be knhibiting the effect of PM. Any advice on that front will be much appreciated.

Hi spanky,

I'm so sorry to hear about you're father and grandfather, when's the last time you had yourself checked?. As far the two together it would seem like a good fit, to be sure I'd ask your PCP if you can. (I'll do more research and see what else's shakes out)



DIM is Diindolylmethane-It is an anti carcinogen and also improves estrogen metabolism. Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells* DIM is remarkably similar in conformational geometry and surface charge distribution to an established synthetic AR antagonist, Taken with estrogen agonist, activities of DIM are seen as an hormone disrupter. DIM is the first example of a pure androgen receptor antagonist from plants.


Dim is also considered an AA. (Estrogen agonist)-an antagonist for estrogen that is used in the treatment of breast cancer, like taking tamoxifen, which is a drug that antagonizes breast cancer cells.

Well, turns out they actually make a product with PM and Dim, said to enhance PM, which to me means the metabolism.

http://www.amazon.com/Natures-Answer-Pue...B003HEVFIW

Hope it helps!

I have some of this stuff and it was the first PM I ordered, I guess I should have read into the ingredients before I bought it

It has ;

Folate (usp folic acid) 200mcd 50% RDA
vitamin B12 (as cyanocobalamin) 500 mcd 8333% RDA (WTF)
biotin 150 mcd 50% rda
Selenium (as selenomethionine) 70 mcd 70% rda
Pueresterol (as Peuraria Mirifica root extract) 100 mg
DIM (di-indoylmethane) 50 mg

So not much PM but WTF why is there so much B12???

[Lotus]

A particular concern of mine is to minimize the risk of prostate cancer, as both my father and grandfather died of it. I have episodically taken DIMM thinking it might help, but grew concerned that it might be knhibiting the effect of PM. Any advice on that front will be much appreciated.

Hi spanky,

I'm so sorry to hear about you're father and grandfather, when's the last time you had yourself checked?. As far the two together it would seem like a good fit, to be sure I'd ask your PCP if you can. (I'll do more research and see what else's shakes out)



DIM is Diindolylmethane-It is an anti carcinogen and also improves estrogen metabolism. Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells* DIM is remarkably similar in conformational geometry and surface charge distribution to an established synthetic AR antagonist, Taken with estrogen agonist, activities of DIM are seen as an hormone disrupter. DIM is the first example of a pure androgen receptor antagonist from plants.


Dim is also considered an AA. (Estrogen agonist)-an antagonist for estrogen that is used in the treatment of breast cancer, like taking tamoxifen, which is a drug that antagonizes breast cancer cells.

Well, turns out they actually make a product with PM and Dim, said to enhance PM, which to me means the metabolism.

http://www.amazon.com/Natures-Answer-Pue...B003HEVFIW

Hope it helps!

I have some of this stuff and it was the first PM I ordered, I guess I should have read into the ingredients before I bought it

It has ;

Folate (usp folic acid) 200mcd 50% RDA
vitamin B12 (as cyanocobalamin) 500 mcd 8333% RDA (WTF)
biotin 150 mcd 50% rda
Selenium (as selenomethionine) 70 mcd 70% rda
Pueresterol (as Peuraria Mirifica root extract) 100 mg
DIM (di-indoylmethane) 50 mg

So not much PM but WTF why is there so much B12???

It supports you're metabolism, B12 helps the breakdown, DIM speeds up the metabolism of E through excretion.

[EvaMarie]

OK Lotus but isnt that a heck of a lot of B12

Jeez I took three of those in one day when I first got em and I was actually feeling a serious effect downstairs rivaling viagra

Thats when I said WTF and read the label, not what I was expecting!!!

I have considered adding one cap a day in place of a Ainterol PM cap/dose (I use the powder and likely too much)...

[Lotus]

OK Lotus but isnt that a heck of a lot of B12

Jeez I took three of those in one day when I first got em and I was actually feeling a serious effect downstairs rivaling viagra

Thats when I said WTF and read the label, not what I was expecting!!!

I have considered adding one cap a day in place of a Ainterol PM cap/dose (I use the powder and likely too much)...

Lol, have you ever checked the supplement facts on those energy shots?, it's about the same.

[girlalex]

A particular concern of mine is to minimize the risk of prostate cancer, as both my father and grandfather died of it. I have episodically taken DIMM thinking it might help, but grew concerned that it might be knhibiting the effect of PM. Any advice on that front will be much appreciated.

Hi spanky,

I'm so sorry to hear about you're father and grandfather, when's the last time you had yourself checked?. As far the two together it would seem like a good fit, to be sure I'd ask your PCP if you can. (I'll do more research and see what else's shakes out)



DIM is Diindolylmethane-It is an anti carcinogen and also improves estrogen metabolism. Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells* DIM is remarkably similar in conformational geometry and surface charge distribution to an established synthetic AR antagonist, Taken with estrogen agonist, activities of DIM are seen as an hormone disrupter. DIM is the first example of a pure androgen receptor antagonist from plants.


Dim is also considered an AA. (Estrogen agonist)-an antagonist for estrogen that is used in the treatment of breast cancer, like taking tamoxifen, which is a drug that antagonizes breast cancer cells.

Well, turns out they actually make a product with PM and Dim, said to enhance PM, which to me means the metabolism.

http://www.amazon.com/Natures-Answer-Pue...B003HEVFIW

Hope it helps!

I have some of this stuff and it was the first PM I ordered, I guess I should have read into the ingredients before I bought it

It has ;

Folate (usp folic acid) 200mcd 50% RDA
vitamin B12 (as cyanocobalamin) 500 mcd 8333% RDA (WTF)
biotin 150 mcd 50% rda
Selenium (as selenomethionine) 70 mcd 70% rda
Pueresterol (as Peuraria Mirifica root extract) 100 mg
DIM (di-indoylmethane) 50 mg

So not much PM but WTF why is there so much B12???

I'm not surprised to hear this. I have been taking PM phytogen complex from solgar and it also has tons of B12 and i don't understand why.
I'm also not surprised that the this brand also made me feel like shit after awhile and its because sure enough after looking up some info on B12 turns out the side effects of this vitamin are anxiety and heart problems. please and thank you very much doush bags who put so much of it in the PM. it absolutly makes no sense for it to have so much b12 its retarted, it must be a filler.

[Lotus]

So is this surprising that the PM extract High 120:1 Potency can be used as follows:


1) Adding to your favorite non-alcohol drink (grapefruit juice for me)

2) Mixed with cream or lotion (no surprise there)

3) Avoid fatty foods, it causes it to be less effective

4) Can be used in vaginal lubricants

5) Aids transgender men for increased breast size (yup!, that's what it says!)

6) Monitor your Progesterone Level (suggests a saliva test)

7) 3-6 drops = 120-240 mg (1 drop is 40 mg)

8) For best results use once per day (Before breakfast)

9) Manufactured using a super critical C02 process (unique and one of a kind)


Yeah, I read the instructions, duh!

Since posting this about 11 days #6 has really made me think about it. Why is it important?. Well I can tell you based on some research that Progesterone can lower thrombosis by 10-15%. What is thrombosis?, it's the formation of blood clots, or can progress to DVT-deep vein thrombosis which commonly affects leg veins, (femoral vein) and causing leg pain.

I also found out that PC is one the strongest 5-ar (5 alpha reductase) out there, that's the enzyme that prevents T to covert to DHT.

It's also a strong oxidizer of blood fats, but basically why they want you (bio-males included) to offset with PC is so it won't cause clotting issues or pain, even if it's simulated E.

Also, when we talk about "Fat Re-Distribution", E is creating the fatty tissues from stimulated fat cells and helping breast growth.