18-04-2014, 01:34 PM
Well Ive decided Im not going to take the Provera for now because it really gives me a headache and after reading everything I can find out about it I cant see any reason to take it
I did take 5 mg of E2 yesterday and the effect felt to me just like taking a very high dose of like 5-6 grams of PM...
I get a mild back ache and sometimes very slight pain in my arms at that high of a dose of PM and it was pretty much exactly the same on the E2...
Ive read the highs and lows on the E are higher and lower sublingually so Ive been going 1 mg at a time throughout the day so far....
Admittedly it hasnt been long for me at all on E though
I can say I felt like I was stalling out a bit on the PM but the E seems to have stopped that for sure
On the PM I could usually feel it go to work right after taking it in my little girls....
First mg of E this morning sure was nice
Shortly after it was dissolved they got that nice little itch and warmth then the good pain stronger than ever for a awhile before calming down a bit
I also could literally feel a bit of a tingle in my nuts at the same time that I never got on PM
Im thinking Im going to ask the doc about going on Prometrium (bio identical micronized progesterone).... But Im not sure I even need progesterone yet... Ive read that it isnt really necessary until you have more mature breasts... It is a 5 AR blocker though supposedly....
Id go with finesteride or dutestreride but Im not sure my insurance would cover that and Im not sure it would be worth it for trying to revive the long gone hair on my bald dome...
So that leaves Spiro...
This stuff looks interesting though and very powerful stuff from what Ive read on it and it might be useful in lower doses than used for prostate cancer... Im no doctor though Id think an endo would be needed to go on this stuff....
Bicalutamide blocks androgen receptors. This prevents testosterone and other androgens from binding to the receptors. Bicalutamide may cause sexual difficulties and a decline in sperm count. Nevertheless bicalutamide monotherapy appears to have minimal effect on sexual activity.[20]
Blockade of androgens receptors by bicalutamide in the brain will eliminate the negative feedback loop of testosterone on the release of luteinizing hormone (LH). This in turn will lead to a dramatic increase in testosterone and estrogen levels.[21] Bicalutamide treatment will block the effects of rising testosterone levels, but the effect of rising estrogen levels will remain unopposed and lead to feminizing effects, the most notable one being gynecomastia, which is often painful.[22]
If bicalutamide is combined with an LHRH agonist or surgical castration then the elevation of estrogen levels will be prevented and the risks of excessive estrogen will be reduced. However, since both testosterone and estrogens are essential for normal bone metabolism, reducing the anabolic bone effects of both androgens (which increase bone formation by stimulating osteoblasts)[23] and estrogens (which reduce bone resorption by inhibiting osteoclasts)[24] will increase bone loss and promote osteoporosis.[25]
https://en.wikipedia.org/wiki/Bicalutamide
I did take 5 mg of E2 yesterday and the effect felt to me just like taking a very high dose of like 5-6 grams of PM...
I get a mild back ache and sometimes very slight pain in my arms at that high of a dose of PM and it was pretty much exactly the same on the E2...
Ive read the highs and lows on the E are higher and lower sublingually so Ive been going 1 mg at a time throughout the day so far....
Admittedly it hasnt been long for me at all on E though
I can say I felt like I was stalling out a bit on the PM but the E seems to have stopped that for sure
On the PM I could usually feel it go to work right after taking it in my little girls....
First mg of E this morning sure was nice
Shortly after it was dissolved they got that nice little itch and warmth then the good pain stronger than ever for a awhile before calming down a bitI also could literally feel a bit of a tingle in my nuts at the same time that I never got on PM
Im thinking Im going to ask the doc about going on Prometrium (bio identical micronized progesterone).... But Im not sure I even need progesterone yet... Ive read that it isnt really necessary until you have more mature breasts... It is a 5 AR blocker though supposedly....
Id go with finesteride or dutestreride but Im not sure my insurance would cover that and Im not sure it would be worth it for trying to revive the long gone hair on my bald dome...
So that leaves Spiro...
This stuff looks interesting though and very powerful stuff from what Ive read on it and it might be useful in lower doses than used for prostate cancer... Im no doctor though
Id think an endo would be needed to go on this stuff....Bicalutamide blocks androgen receptors. This prevents testosterone and other androgens from binding to the receptors. Bicalutamide may cause sexual difficulties and a decline in sperm count. Nevertheless bicalutamide monotherapy appears to have minimal effect on sexual activity.[20]
Blockade of androgens receptors by bicalutamide in the brain will eliminate the negative feedback loop of testosterone on the release of luteinizing hormone (LH). This in turn will lead to a dramatic increase in testosterone and estrogen levels.[21] Bicalutamide treatment will block the effects of rising testosterone levels, but the effect of rising estrogen levels will remain unopposed and lead to feminizing effects, the most notable one being gynecomastia, which is often painful.[22]
If bicalutamide is combined with an LHRH agonist or surgical castration then the elevation of estrogen levels will be prevented and the risks of excessive estrogen will be reduced. However, since both testosterone and estrogens are essential for normal bone metabolism, reducing the anabolic bone effects of both androgens (which increase bone formation by stimulating osteoblasts)[23] and estrogens (which reduce bone resorption by inhibiting osteoclasts)[24] will increase bone loss and promote osteoporosis.[25]
https://en.wikipedia.org/wiki/Bicalutamide