14-08-2014, 02:01 PM
Well I guess I should be OK according to this study anyway Im just wondering how things will settle out in time... I guess with a weekly shot the E level would be pretty constant high... 5mg weekly sounds like plenty and If my insurance wont cover the injectibles I might just try that just to save $$$.... They are currently covering my oral E and spiro 100% so they might cover the injections... If not a five week supply is $122.00 at 10mg weekly.... The savings could be significant.... Thats still cheaper than my gel/patch/oral regime though.....
Intramuscular administration of estradiol
esters
After intramuscular injection of an oily solution of
fatty acid esters of estradiol, the solvent i
absorbed, leading to a primary microcrystalline
depot at the injection site. Moreover, a secondary
depot in fat tissue may also be formed. The ester is
released at a slow rate and hydrolyzed in the liver
and other organs. The longer the fatty acid chain,
the more lipophilic is the ester, the more prolonged
is the time course of the serum concentration
curve, the more protracted is the duration of action
and the lower are the serum concentrations of
estradiol. The estrone levels are only half those of
estradiol. After the injection of 4 mg estradiol
valerate, a maximal serum level of 400 pg/ml is
reached after 2 days, which thereafter decreased to
150 pg/ml within 10 days (Figure 7)
151
. The
injection of 5 mg of the more lipophilic estradiol
cyclopentylpropionate (cypionate) caused a peak
level of 340 pg/ml estradiol after 4 days, which
was followed by a slow decline to a value of
50 pg/ml not before 2 weeks. The serum maximum
of estrone was only 145 pg/ml
152
.
http://www.hormonebalance.org/images/doc...cteric.pdf
Intramuscular administration of estradiol
esters
After intramuscular injection of an oily solution of
fatty acid esters of estradiol, the solvent i
absorbed, leading to a primary microcrystalline
depot at the injection site. Moreover, a secondary
depot in fat tissue may also be formed. The ester is
released at a slow rate and hydrolyzed in the liver
and other organs. The longer the fatty acid chain,
the more lipophilic is the ester, the more prolonged
is the time course of the serum concentration
curve, the more protracted is the duration of action
and the lower are the serum concentrations of
estradiol. The estrone levels are only half those of
estradiol. After the injection of 4 mg estradiol
valerate, a maximal serum level of 400 pg/ml is
reached after 2 days, which thereafter decreased to
150 pg/ml within 10 days (Figure 7)
151
. The
injection of 5 mg of the more lipophilic estradiol
cyclopentylpropionate (cypionate) caused a peak
level of 340 pg/ml estradiol after 4 days, which
was followed by a slow decline to a value of
50 pg/ml not before 2 weeks. The serum maximum
of estrone was only 145 pg/ml
152
.
http://www.hormonebalance.org/images/doc...cteric.pdf