Why increasing the dosage doesn't always work
Negative feedback occurs when the result of a process influences the operation of the process itself in such a way as to reduce changes. Feedback can produce stability and reduce the effect of fluctuations. Negative feedback loops in which just the right amount of correction is applied in the most timely manner can be very stable, accurate, and responsive. In other words, do you remember your body made changes when starting PM or E2?, some good changes did occur, however, the changes in testosterone made your testicles feel like it was going explode.
Negative feedback loops have been compared to a thermostatically controlled temperature in a house, where the internal temperature is monitored by a temperature-sensitive gauge in the thermostat. If it is cold outside, eventually the internal temperature of the house drops, as cold air seeps in through the walls. When the temperature drops below the point at which the thermostat is set, the thermostat turns on the furnace. As the temperature within the house rises, the thermostat again senses this change and turns off the furnace when the internal temperature reaches the pre-set point.
Negative feedback loops require a receptor, a control center, and an effector. A receptor is the structure that monitors internal conditions. For instance, the human body has receptors in the blood vessels that monitor the pH of the blood. The blood vessels contain receptors that measure the resistance of blood flow against the vessel walls, thus monitoring blood pressure. Receptors sense changes in function and initiate the body's homeostatic response. Cycling NBE or NBE will diminish blood levels of PM and ESTRADIOL, and you'll feel like crap because you've interrupted the steady state of delivery from former and latter. CYCLING NBE or HRT ISN'T NECESSARY, DESPITE SOMEONE SPAMMING OTHERWISE (CONTRARY TO THE ABOVE STATEMENT). TO RECAP, YOU'LL REDUCE YOUR BLOOD LEVELS OF NBE/HRT by cycling upsetting the apple cart.
The goal (when doing NBE/HRT) is keeping a steady state of PM/E2... even for
Read more: Homeostasis - Negative feedback - Body, Blood, Internal, and Conditions - JRank Articles http://science.jrank.org/pages/3365/Home...z34AWy8WWP
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Cycling supplements isn't for NBE/HRT. Once your body makes the adjustments to get back to homeostasis (from the negative feedback loop of starting NBE/HRT) you're body will fight you to keep at your current NBE/HRT levels.