03-04-2015, 05:25 PM
hi Clelia,
The main phyto's of choice at BN is Puearari Mirifica. There variance in potency is a big concern since its been stated its most effective yield is at 10 years for the root tubers. And out of that its only 2 months out of the year. Distributors don't share potency/yield/heavy metal tests etc. Its been stated PM is .25% of estradiol, but it's more like .006 in ER-a and double that in ER-b (or there about). Some of our BN members have had some serious side effects. They range from severe headaches to major bleeding in menstration. I'll provide the threads later. From what I've been able to determine PM up-regulates triglycerides (just like E2), increased blood flow, which I believe interupts with sleep, (as some have reported) and an initial libido increase (again, imo increased blood supply). I'd like to explore any and all interactions if possible. Here's one link to start with.
Down regulation of gene related sex hormone synthesis pathway in mouse testes by miroestrol and deoxymiroestrol.
Abstract
Miroestrol and deoxymiroestrol are phytoestrogens isolated from tuberous root of Pueraria candollei var. mirifica. Modulatory effects of miroestrol and deoxymiroestrol on enzymes involved in sex-hormone synthesis pathway in male C57BL/6 mice were investigated using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). Miroestrol and deoxymiroestrol suppressed the expressions of 3β-HSD, 17β-HSD1, and CYP17 while CYP19 mRNA expression was slightly decreased. In addition, the expression of 17β-HSD2 was induced in correlation with those did by estradiol. These observations supported that miroestrol and deoxymiroestrol could exhibit the same effect as estradiol regarding regulation of testicular gene related sex hormone synthesis pathway.
Copyright © 2011 Elsevier B.V. All rights reserved.
http://www.ncbi.nlm.nih.gov/pubmed/21856387
The main phyto's of choice at BN is Puearari Mirifica. There variance in potency is a big concern since its been stated its most effective yield is at 10 years for the root tubers. And out of that its only 2 months out of the year. Distributors don't share potency/yield/heavy metal tests etc. Its been stated PM is .25% of estradiol, but it's more like .006 in ER-a and double that in ER-b (or there about). Some of our BN members have had some serious side effects. They range from severe headaches to major bleeding in menstration. I'll provide the threads later. From what I've been able to determine PM up-regulates triglycerides (just like E2), increased blood flow, which I believe interupts with sleep, (as some have reported) and an initial libido increase (again, imo increased blood supply). I'd like to explore any and all interactions if possible. Here's one link to start with.
Down regulation of gene related sex hormone synthesis pathway in mouse testes by miroestrol and deoxymiroestrol.
Abstract
Miroestrol and deoxymiroestrol are phytoestrogens isolated from tuberous root of Pueraria candollei var. mirifica. Modulatory effects of miroestrol and deoxymiroestrol on enzymes involved in sex-hormone synthesis pathway in male C57BL/6 mice were investigated using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). Miroestrol and deoxymiroestrol suppressed the expressions of 3β-HSD, 17β-HSD1, and CYP17 while CYP19 mRNA expression was slightly decreased. In addition, the expression of 17β-HSD2 was induced in correlation with those did by estradiol. These observations supported that miroestrol and deoxymiroestrol could exhibit the same effect as estradiol regarding regulation of testicular gene related sex hormone synthesis pathway.
Copyright © 2011 Elsevier B.V. All rights reserved.
http://www.ncbi.nlm.nih.gov/pubmed/21856387