[tanysquirrel]

so I had made an interesting discovery of information about the effect of menthol and the enhanced bio-available role of absorbtion of various chemicals, alcohol in particular. this serves the fact (as mentioned in my acorns of research thread under 'menthol' ), that it will possibly work perfectly in upregulating the Bovine Ovary Vodka or Porcine Ovary Vodka, through the skin into the adipose tissue (fat).
"RE: Squirrel's horded acorns of information ( cache of research info)

menthol
https://en.wikipedia.org/wiki/Menthol
Some studies show that menthol acts as GABAA receptor positive allosteric modulator and increases GABAergic transmission in PAG neurons.[5] Menthol also shares anaesthetic properties similar to propofol, by modulating same sites of GABAA receptor.[6]
GABAA_receptor_positive_allosteric_modulator:
In pharmacology, GABAA receptor positive allosteric modulators are positive allosteric modulator (PAM) molecules that increase the activity of the GABAA receptor protein in the vertebrate central nervous system. Unlike GABAA receptor agonists, GABAA PAMs do not bind at the same active site as the γ-Aminobutyric acid (GABA) neurotransmitter molecule: PAMs affect the receptor by binding at a different site on the protein. This is called allosteric modulation

GABA is a major inhibitory neurotransmitter in the Central nervous system. Upon binding, it triggers the GABAA receptor to open its chloride channel to allow chlorine ions into the neuron, making the cell hyperpolarized and less likely to fire. GABAA PAMs bind to a different site and increase the effect of GABA by making the channel open more frequently or for longer when GABA binds. However, they do not have an effect if GABA or another agonist is not present.

In psychopharmacology, GABAA receptor PAMs used as drugs have mainly sedative and anxiolytic effects. Examples of GABAA PAMs include alcohol (ethanol), benzodiazepines such as diazepam (Valium) and alprazolam (Xanax), Z-drugs such as zolpidem (Ambien), and the barbiturate drugs.

Biosynthesis of Neurosteroids[edit]

Neurosteroids are synthesized in the central nervous system (CNS) and the peripheral nervous system (PNS) from cholesterol and steroidal precursors that are imported from the peripheral sources. These sources include 3β-hydroxy-Δ5 derivatives, such as pregnenolone (PREG) and dehydroepiandrosterone (DHEA), their sulfates, and reduced metabolites such as the tetrahydro derivative of progesterone 3α-hydroxy-5α-pregnane-20-one (3α,5α-THPROG). After the local synthesis or from metabolism of adrenal of gonadal steroids many neurosteroids accumulate in the brain.[26][27]

interesting, so in theory, since Menthol absorbs alcohol trandermaly, then perhaps the Bovine ovary Vodka , or even a PM lotion or cream will accelerate in effect as theorized in the GABAA PAMs...
tests and trials may be needed. "

one of the possible side effects is : instant hangover effect. this may be dose-dependent.

but in theory, if addition to menthol to the BOV final concoction (bovine ovary vodka in carrier lotion), the menthol will help significantly.

eucalyptus, peppermint.. any type of menthol, menthol vapor rub, etc.. so long as it produces a "cool" effect of mentholated effect when applied to skin. I am sure that in ratio, a 1:2:1 would be sufficient, (1 part menthol substance to two parts BOV to one part lotion). the purpose of the lotion is to be the carrier. it is ok If the lotion is a bit watery with the addition of the BOV.. allowed to air for a few hrs(evaporate ) alcohol, should mitigate the "hangover" effect- testing needed).

Oh interesting! Maybe I can add a peppermint hydrosol when I mix it with the BOV and CO? Or find/create a peppermint based lotion. It sounds like it would have nice cooling effect on the skin. Good finding!

I suppose you can pre-mix it all in advance., after you have extracted the bovine ovary in vodka. if you do it before, it might interfere with the extracting process.. when I say premix it in advance, I am thinking after the extraction and mix with menthol and lotion, let that set up for a day or so, then use during breast massage and the like and yes, it has a very menthol feel to it.. I had used some menthol rub I had on hand ....felt quite a few aches down below in my unwanted portion of this body. so I know it works..