17-02-2018, 12:55 PM
so the question is:
Does the introduction of Fox gene laden bovine ovary pills , trigger the Changes that some see on Bovine ovary pills?
does the harvesting of the bovine ovaries at certain times , rely on the amount of Fox at time of harvest? does this indicate why it works for some, and not for others?
http://www.bioone.org/doi/abs/10.1095/bi...lCode=bire
FOXL2, a winged-helix/forkhead domain transcription factor, is a key gene involved in the differentiation and biological functions of the ovary. In a recent transcriptomic analysis, we found that [i]FOXL2[/i] expression in bovine caruncular endometrium was different from that in intercaruncular endometrium. In order to gain new insights into FOXL2 in this tissue, we determined the expression of this transcription factor during the estrous cycle and the establishment of pregnancy in cattle. The endometrial expression of [i]FOXL2[/i] did not vary during maternal recognition of pregnancy (Days 16–20). Using an in vivo bovine model and primary cell cultures, we showed that [i]FOXL2[/i] was not an interferon-tau target gene. Both [i]FOXL2[/i] transcript and protein were expressed from Day 5 to Day 20 of the estrous cycle, and their levels showed a significant increase during the luteolytic phase. A 2-day progesterone supplementation in heifers led to a clear down-regulation of FOXL2 protein levels, suggesting the negative impact of progesterone on [i]FOXL2[/i] expression. Immunohistochemistry data revealed the localization of FOXL2 in endometrial stromal and glandular cells. FOXL2 subcellular distribution was shown to be nuclear in endometrial samples collected during the luteolytic period, while it was not detected in nuclei during the luteal phase and at implantation. Collectively, our findings provide the first evidence that FOXL2 is involved in the regulation of endometrial tissue physiology.
Does the introduction of Fox gene laden bovine ovary pills , trigger the Changes that some see on Bovine ovary pills?
does the harvesting of the bovine ovaries at certain times , rely on the amount of Fox at time of harvest? does this indicate why it works for some, and not for others?
http://www.bioone.org/doi/abs/10.1095/bi...lCode=bire
FOXL2, a winged-helix/forkhead domain transcription factor, is a key gene involved in the differentiation and biological functions of the ovary. In a recent transcriptomic analysis, we found that [i]FOXL2[/i] expression in bovine caruncular endometrium was different from that in intercaruncular endometrium. In order to gain new insights into FOXL2 in this tissue, we determined the expression of this transcription factor during the estrous cycle and the establishment of pregnancy in cattle. The endometrial expression of [i]FOXL2[/i] did not vary during maternal recognition of pregnancy (Days 16–20). Using an in vivo bovine model and primary cell cultures, we showed that [i]FOXL2[/i] was not an interferon-tau target gene. Both [i]FOXL2[/i] transcript and protein were expressed from Day 5 to Day 20 of the estrous cycle, and their levels showed a significant increase during the luteolytic phase. A 2-day progesterone supplementation in heifers led to a clear down-regulation of FOXL2 protein levels, suggesting the negative impact of progesterone on [i]FOXL2[/i] expression. Immunohistochemistry data revealed the localization of FOXL2 in endometrial stromal and glandular cells. FOXL2 subcellular distribution was shown to be nuclear in endometrial samples collected during the luteolytic period, while it was not detected in nuclei during the luteal phase and at implantation. Collectively, our findings provide the first evidence that FOXL2 is involved in the regulation of endometrial tissue physiology.