21-03-2018, 02:57 PM
remember: Adrenal glands also produce FOXL2...
https://bioinformaticsreview.com/2017072...y-failure/
When FOXL2 binds to SF1, it upregulates CYP19 aromatase expression and inhibits CYP17 expression which is mediated by unbound SF1. Therefore, FOXL2 plays a major role in balancing the levels of androgen (CYP17) and estrogen (CYP17). It has been observed that mutations in the SF1 lead to male-to-female sex reversal in humans [32] and FOXL2 missense mutation leads to female-to-male sex reversal in goats [33]. The interaction of FOXL2 with SF1 also upregulates Mc2r [34], which codes for an ACTH receptor required for steroidogenesis and adrenal gland development [1]. Upon interaction with ERα, it prevents the binding of ERα to PTGS2 promoter. Not much is known about the impact of the interaction of FOXL2 to ERα on another target of ERα [35].
SF1 gene:
https://en.wikipedia.org/wiki/SF1_(gene)
Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.[3][4][5]
Splicing factor SF1 is involved in the ATP-dependent formation of the spliceosome complex.[6
Sooo, now how to figure out how to mutate the SF1 gene.... The plot thickens...
https://bioinformaticsreview.com/2017072...y-failure/
When FOXL2 binds to SF1, it upregulates CYP19 aromatase expression and inhibits CYP17 expression which is mediated by unbound SF1. Therefore, FOXL2 plays a major role in balancing the levels of androgen (CYP17) and estrogen (CYP17). It has been observed that mutations in the SF1 lead to male-to-female sex reversal in humans [32] and FOXL2 missense mutation leads to female-to-male sex reversal in goats [33]. The interaction of FOXL2 with SF1 also upregulates Mc2r [34], which codes for an ACTH receptor required for steroidogenesis and adrenal gland development [1]. Upon interaction with ERα, it prevents the binding of ERα to PTGS2 promoter. Not much is known about the impact of the interaction of FOXL2 to ERα on another target of ERα [35].
SF1 gene:
https://en.wikipedia.org/wiki/SF1_(gene)
Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.[3][4][5]
Splicing factor SF1 is involved in the ATP-dependent formation of the spliceosome complex.[6
Sooo, now how to figure out how to mutate the SF1 gene.... The plot thickens...