Though a regular lurker, I had to add my own take on this. I recently confirmed a condition I've had since early teens, that being estrogen-dependent hereditary angioedema. The reason I bring this up is that taking PM verified that estrogen dominance is the cause. Another reason is the mention of pains and otherwise yuckiness. Angioedema is VERY hard to diagnose, and normally causes external swelling (edema) but also includes internal swelling, up to and including anaphylaxis (bummer, no doubt). I recently had a bout of what the emergency room determined to be enteritis, but it only started after ramping up my PM dose. The point I'm making is that PM seems to work, but must be balanced with progesterone, as AbiDrew85 suggested. Mine seems to ease with FG taken along with the PM, but still working that slow process of discovery.