(27-07-2024, 01:27 AM)Shirazmn Wrote: First: I am not a doctor, so take this with a pinch of salt. Every substance has dosage depending on age and body mass. PM's suggested dosage is 1000 mg/day, but that's for genetic women who weight what? 60/70 kg? I think a 130kg person should go for almost double the dosage. Plus, genetic males don't even have any basic natural estrogen production, so a higher dose could be excused.
Agreed. Except:
I was with you until you said that "genetic males don't even have any basic natural estrogen production"
Genetic males do produce estrogen. It gets converted to estrogen (17b-Estradiol (E2)) from Testosterone by way of the Aromatase enzyme (P450 Aromatase). Androstenedione (an androgen) also gets converted to either 17a-Estradiol (a-E2) via Aromatase, or to Estrone (E1) via Aromatase.
I think that's one of the reasons why Lotus' signature has this:
Quote:♦NBE Formula→Free Testosterone→5 alpha inhibitors→Aromatase→E1/E2....DNA→RNA→Protein ♦
♦Regulation of Estrogen & Progesterone-Hypothalamus→GnRH→Pituitary→FSH→Follicle→Estrogens ♦
♦ego cogito, ergo sum TG.
I think the theory above is to increase Testosterone, decrease DHT (by using 5-AR inhibitors), to elevate Free Testosterone, to then force as much of this Free Testosterone to convert to Estrogens via the Aromatase enzyme. And this then gets men... real boobs!
(not too sure about the DNA/RNA/Protein section, but I need to study about that part of biology)
And I suppose that the above might indicate that a person might not need PM? PM is a phytoestrogen (I think that means it gets used by the body and then transported to cells, where it binds with estrogen receptors and tells them "hi! I'm estrogen! Do your thing that the DNA/RNA tells you to do, if you were getting real estrogen.", and then the cell (e.g. breasts) start building "stuff" like mamary glands and fat accumulation and shaping, and make extra nerves etc)
I'm not a biologist or a doctor. I'm in STEM though. There's a fair chance that I'm wrong. However, this is my actual understanding from all the notes I've so far built while reading this forum, and the Reddit NBE subreddit, and other trans-related topics. @Lotus, how far off am I?