[julieTG]

DUAL-GENDER MACRO-CHIMERIC TISSUE DISCORDANCE IS PREDICTED TO BE A SIGNIFICANT CAUSE OF HUMAN HOMOSEXUALITY AND TRANSGENDERISM
Brian P Hanley

ABSTRACT

I present literature evidence that suggests that human chimerism may be quite common, occurring in between 5% and 15% of people. Chimerism has been believed to be rare because it usually presents without visible phenotype. In addition to the documented occurrence of dual gender macrochimeras with true hermaphrodite phenotype, there are reports of the occurrence of other natural human macrochimeras. The literature reviewed in this paper suggests that such macrochimerism is much more common than usually appreciated. Chimerism occurs in a patchy manner, with male cells outgrowing female in macrochimerism causing the majority to be phenotypically male. The literature also suggests that the sex of nervous system tissue is the primary determinant in higher animals of sexual attraction. From this, the existence of human macrochimeras in which large proportions of cells are male and female is predicted to have a correlation with homosexuality and transgender self-identification because in many such cases, the central nervous system, or crucial parts of it, will be of one sex and the gonads and body form will be of the opposite sex. I describe experiments to further clarify this hypothesis, which can also have potential benefit beyond this specific question.


KEYWORDS

homosexuality; homosexual; transgenderism; transgender; chimerism; chimera; macro-chimerism; macro-chimera; tetragametic; dispermic; gender discordance

FULL TEXT:

[Lotus]

Macro-what?,

Are they talking about in the womb?

[Robindee36]

Is there an English (US version) of this I speak engineer not biochemist.

Hugs (and giggling a bit) Robin

[sfem]

You could always see if the wikipedia entry for chimera makes more sense to you.

It's a potentially interesting area of research although restrictions on human experimentation will likely keep us from learning too much about how it might relate to folks like us for a long time. I'd like to think I'm overly pessimistic, but since I also don't see how there is money to be made from the research, I'm guessing my pessimism might be warranted.

[Pansy-Mae]

You could always see if the wikipedia entry for chimera makes more sense to you.

I already tried that...it isn't much less technical than the original paper that Julie quoted!

However on a not unrelated topic this BBC item from yesterday is also of potential interest.
http://www.bbc.co.uk/news/health-24991843

[Jessica Leigh]

This is something I have always "felt" was true. Very interesting hypothesis.

And maybe someday with gene therapy one could drink an elixir that could fix our y chromosomes - changing them to x. Or vice versa.

But would our families, friends, and coworkers be anymore excepting....