21-03-2020, 04:17 PM
(This post was last modified: 21-03-2020, 04:39 PM by VergeOfDiscovery.)
The quinine in the tonic water of today is minimal and is mainly a flavoring agent that hearkens back to a time when it contained more of the stuff and quinine was recognized for it's anti malarial properties.
Quinine is directly related to the Chloroquine and Hydroxychloroquine touted recently in Trump's COVID-19 briefings.
The mechanism of action is similar...
Quinine is theorized to be toxic to the malarial pathogen, Plasmodium falciparum, by interfering with the parasite's ability to dissolve and metabolize hemoglobin.[32] As with other quinoline antimalarial drugs, the mechanism of action of quinine has not been fully resolved.[medical citation needed] The most widely accepted hypothesis of its action is based on the well-studied and closely related quinoline drug, chloroquine. This model involves the inhibition of hemozoin biocrystallization in Heme Detoxification pathway, which facilitates the aggregation of cytotoxic heme. Free cytotoxic heme accumulates in the parasites, causing their deaths.[33] Quinine may target malaria's purine nucleoside phosphorylase enzyme.
https://en.wikipedia.org/wiki/Quinine
https://en.wikipedia.org/wiki/Hydroxychloroquine
This in a strange way reminds me of how Cholecalciferol, commonly known and used as Vitamin D3 supplement, is the key component of rat poison. It kills by a life threatening increase in blood calcium (Hypercalcaemia). Size definitely matters when it comes to whether things like these are either beneficial or detrimental.
https://www.petpoisonhelpline.com/poison...alciferol/
https://en.wikipedia.org/wiki/Rodenticide
Hydroxychloroquine itself is not without risk (which perhaps is one of the reasons not everyone is in a rush to simply give it to people without further testing and such) and prolonged use (using it in the context of COVID-19 would likely not entail long term use) can be particularly detrimental to the eyes.
https://en.wikipedia.org/wiki/Chloroquine_retinopathy
Quinine is directly related to the Chloroquine and Hydroxychloroquine touted recently in Trump's COVID-19 briefings.
The mechanism of action is similar...
Quinine is theorized to be toxic to the malarial pathogen, Plasmodium falciparum, by interfering with the parasite's ability to dissolve and metabolize hemoglobin.[32] As with other quinoline antimalarial drugs, the mechanism of action of quinine has not been fully resolved.[medical citation needed] The most widely accepted hypothesis of its action is based on the well-studied and closely related quinoline drug, chloroquine. This model involves the inhibition of hemozoin biocrystallization in Heme Detoxification pathway, which facilitates the aggregation of cytotoxic heme. Free cytotoxic heme accumulates in the parasites, causing their deaths.[33] Quinine may target malaria's purine nucleoside phosphorylase enzyme.
https://en.wikipedia.org/wiki/Quinine
https://en.wikipedia.org/wiki/Hydroxychloroquine
This in a strange way reminds me of how Cholecalciferol, commonly known and used as Vitamin D3 supplement, is the key component of rat poison. It kills by a life threatening increase in blood calcium (Hypercalcaemia). Size definitely matters when it comes to whether things like these are either beneficial or detrimental.
https://www.petpoisonhelpline.com/poison...alciferol/
https://en.wikipedia.org/wiki/Rodenticide
Hydroxychloroquine itself is not without risk (which perhaps is one of the reasons not everyone is in a rush to simply give it to people without further testing and such) and prolonged use (using it in the context of COVID-19 would likely not entail long term use) can be particularly detrimental to the eyes.
https://en.wikipedia.org/wiki/Chloroquine_retinopathy