(09-01-2016, 06:52 PM)iaboy Wrote: (09-01-2016, 06:40 AM)Lotus Wrote: So, bottom line. If PM is authentic it will equal to about .5mg of E2, that's my opinion FWIW. The reason I say .5 (a rough calculation) is that deoxymiroestrol is 10x stronger than Miroestrol, as this is left out in previous valuations.
Based on what...???? 500mg, 1000mg, 1500mg in capsules?? Like Ainterol's??
It would be great to know that. That way peeps not out of the closet with their doctor's and diy's could adjust with out poisoning themselves.
Sorry bout that, I was going by 500mg, however, for women I think they should only take 100 mg doses.
I've done more digging on PM too, (nod to xxd, he'll know what I mean). For instance, I still have an issue with my eye from when I used BO, (pressure and excess tear duct flow) it messes with me vision, aye!. (Plays tricks on me, e.g. typing lol)
anyways.......I find that PM induces expression of the enzyme CYP1B1, which is active in many tissues, including structures of the eye.
Pm induces the expression of the enzyme CYP1B1 (which is explained as follows)
The function of the CYP1B1 enzyme in the development of the eye is unclear, but it may play a role in forming structures at the front of the eye and may also be involved in a process that regulates the secretion of fluid inside the eye.
http://ghr.nlm.nih.gov/gene/CYP1B1
Quote:CYP1B1 was induced by deoxymiroestrol, in which the gene expressions were time- and concentration-dependent patterns compared to those of estradiol.
Now, I also see this as an explanation of the optic migraines (jannet and others), which lead to glaucoma. Hint, I believe this has already been seen in a few cases here.
miroestrol and deoxymiroestrol might affect hepatic P450 enzymes, including the CYP2B9 and CYP1A2 P450 isoforms. More on this upcoming: it'll surprise you (about PM)