[Lotus]

i am suffering from boob envy I need to turbo some green tea apparently

so I bought this one (on amazon) : http://www.iherb.com/Now-Foods-EGCg-Gree...Caps/11598

Anti-cancer therapy targets the inhibition of androgen receptors, making them a strong anti-androgens. Green tea, red reishi provide anti-cancer and inhibition of dht .



Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents.
Review article
Agarwal R. Biochem Pharmacol. 2000.
Show full citation
Abstract
Prostate cancer (PCA) is the most common invasive malignancy and leading cause (after lung) of cancer deaths in males. Since PCA is initially androgen-dependent, strategies are targeted toward androgen depletion for its control. However, tumor re-growth mostly occurs following this modality, and is androgen-independent. A loss of functional androgen receptor and an enhanced expression of growth factor receptors (e.g. erbB family members) and associated ligands have been shown to be the causal genetic events in PCA progression. These genetic alterations lead to an epigenetic mechanism where a feed-back autocrine loop between membrane receptor (e.g. epidermal growth factor receptor [erbB1] and associated ligand (e.g. transforming growth factor-alpha) results in an enhanced activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) as an essential component of the uncontrolled growth of PCA at an advanced and androgen-independent stage. Together, we rationalized that inhibiting these epigenetic events would be useful in controlling advanced PCA growth. Dietary polyphenolic flavonoids and isoflavones are being studied extensively as cancer-preventive and interventive agents. Therefore, we focused our attention on silymarin, genistein, and epigallocatechin 3-gallate (EGCG), present in milk thistle, soy beans, and green tea, respectively. The effect of these agents was assessed on the erbB1-Shc-ERK1/2 signal transduction pathway, cell cycle regulatory molecules, and cell growth and death. In androgen-independent human prostate carcinoma DU145 cells, silymarin, genistein, and EGCG resulted in a significant to complete inhibition of transforming growth factor-alpha-caused activation of membrane receptor erbB1 followed by inhibition of downstream cytoplasmic signaling target Shc activation and a decrease in its binding with erbB1, without an alteration in their protein expression. Silymarin and genistein also inhibited ERK1/2 activation, suggesting that these agents impair the activation of erbB1-Shc-ERK1/2 signaling in DU145 cells. In the case of EGCG, a further increase in ERK1/2 activation was observed that was related to its pro-oxidant and apoptotic activities. Silymarin, genistein, and EGCG also resulted in a significant induction of Cip1/p21 and Kip1/p27 and a decrease in cyclin-dependent kinase (CDK) 4, but a moderate inhibition of CDK2, cyclin D1, and cyclin E was observed. An enhanced level of Cip1/p21 and Kip1/27 also led to an increase in their binding to CDK4 and CDK2. Treatment of cells with silymarin, genistein, and EGCG also resulted in strong cell growth inhibition at lower doses, and complete inhibition at higher doses. In contrast to silymarin, higher doses of genistein also showed cell death. A more profound cytotoxic effect was observed in the case of EGCG, with strong cell death at lower doses and complete loss of viability at higher doses. Together, these results suggest that cell signaling and regulators of cell cycle are potential epigenetic molecular targets for prostate cancer prevention by dietary agents. More studies, therefore, are needed with these agents to explore their anticarcinogenic potential against human prostate cancer.
https://www.ncbi.nlm.nih.gov/m/pubmed/11007941/?i=3&from=/16954429/related

[Lotus]

Inhibition of the CYP3A4 enzyme inhibits androgens in the liver and intestines.

This is worth mentioning again,

Lemons inhibit CYP3A4, and @ 60%?.......,,,,,,,,its pro breast growth.

Application to drug-food interactions of living cells as in vitro model expressing cytochrome P450 activity: enzyme inhibition by lemon juice.
Baltes MR1, Dubois JG, Hanocq M.
Author information
Abstract
Classical inhibitors of human cytochrome P450 3A4 activity, such as ketoconazole and quercetin, are tested to prove the efficiency of a new metabolisation model using living entire cells. Grapefruit juice is a well-known potent inhibitor of cytochrome P450 3A4 activity. With regard to the clinical relevance of grapefruit juice-drug interactions, an investigation of other common juices is undertaken with this in vitro model. The CYP3A4 activity is measured by the formation of the 6beta-hydroxytestosterone, which is quantified by an isocratic high performance liquid chromatography. It is demonstrated for the first time that lemon juice significantly inhibits by 60+/-3% the CYP3A4-mediated oxidation. Grapefruit juice inhibits this activity by 82+/-4%. The mechanism of lemon juice inhibition is competitive, whereas it is mixed for grapefruit juice. These results suggest that our in vitro model combined with our analytical method is applicable for the investigation of the inhibition of CYP3A4 not only by chemical inhibitors but also by natural food products.


Whole Lemons are fairly inexpensive, in drinks or on food.....lemons boost the NBE/Hrt blood levels by the CYP3A4 enzyme pathway.......meaning most the drugs in your medicine cabinet.

[tanysquirrel]

that is a good benefit from the green tea. I am hoping that the ones I got will do the trick. I had previously tried the GTE that was part of a weight loss pill.

How much should I take and at what time of day? morning. night? split dose? how much per split dose?

[tanysquirrel]

Inhibition of the CYP3A4 enzyme inhibits androgens in the liver and intestines.

This is worth mentioning again,

Lemons inhibit CYP3A4, and @ 60%?.......,,,,,,,,its pro breast growth.

Application to drug-food interactions of living cells as in vitro model expressing cytochrome P450 activity: enzyme inhibition by lemon juice.
Baltes MR1, Dubois JG, Hanocq M.
Author information
Abstract
Classical inhibitors of human cytochrome P450 3A4 activity, such as ketoconazole and quercetin, are tested to prove the efficiency of a new metabolisation model using living entire cells. Grapefruit juice is a well-known potent inhibitor of cytochrome P450 3A4 activity. With regard to the clinical relevance of grapefruit juice-drug interactions, an investigation of other common juices is undertaken with this in vitro model. The CYP3A4 activity is measured by the formation of the 6beta-hydroxytestosterone, which is quantified by an isocratic high performance liquid chromatography. It is demonstrated for the first time that lemon juice significantly inhibits by 60+/-3% the CYP3A4-mediated oxidation. Grapefruit juice inhibits this activity by 82+/-4%. The mechanism of lemon juice inhibition is competitive, whereas it is mixed for grapefruit juice. These results suggest that our in vitro model combined with our analytical method is applicable for the investigation of the inhibition of CYP3A4 not only by chemical inhibitors but also by natural food products.


Whole Lemons are fairly inexpensive, in drinks or on food.....lemons boost the NBE/Hrt blood levels by the CYP3A4 enzyme pathway.......meaning most the drugs in your medicine cabinet.

would real lemon extract or lemon juice be as good? better? worse?

[Lotus]

I'll give an example of taking (using) specific anti-androgens, confirmed by labs.

The HRT meds (under doctors care) I started in October was 2 mg of E2 and 50mg spiro, hardly a full HrT program no?. However, because I used lemons, drank green tea , oranges (coffee too) which all inhibit cyp3A4 , my test results show a 1.3% freeT and 26% total (floating) androgens, estrogen was 3x higher than normal, +800 pg/mL. So what happened?, clearly the bioavailability was changed by these additions.

Recent labs show the same thing, however the dosage is changed, E2 4mg and spiro is at 100 mg.

Bottom line, we can speculate all day long about which supplement does xyz, or........we can start using real test result verified by labs, like what Fire did.

[Lotus]

would real lemon extract or lemon juice be as good? better? worse?

Good question, I think it does the same thing, take a look at this anti-cancer study using limonoids:

The Potential of Citrus Limonoids as Anticancer Agents
http://ucce.ucdavis.edu/files/datastore/234-200.pdf

[Lotus]

The quickest way towards feminization,

• Liver activation of protein/enzymes & hormones
  
• Growth Hormone signal via CYP2AB enzyme
  
• Increased GH (growth hormone) secretion via the hypothalamus
  
• Inhibit lutenizing hormone
  

NBE key tools

• 
  Foods
  
• Lemons, oranges, red pigment fruits and veggies.....all of which inhibits CYP17 enzyme (a key enzyme in the steroid biosynthesis of androgens)
  
• Green tea-also a CYP17 inhibitor / also a CYP19 promoter (aka-aromatase)
  
• walnuts (1/4 cup) 2-3x a week, pro ER-a, antioxidant, w-6 fatty acid
  
• Drink (min) 4 cups of green tea daily (80-98% polyphenols)
  
• Drink filtered water 6-8 cups (add a slice of fresh lemon)
  
• Get 10 minutes of high intensity work outs 3-4x a week
  
• Reduce coffee (1 cup per day)
  
• Add protein and healthly fats
  
  _____________________________
  
  Supplements
  
• White peony extract (2-3 per day) pro-aromatase, 5 alpha reductase inhibitor (inhibits DHT).
  
• Red clover extract (1-2 per day)......,low progesterone effect, pro-estrogen alpha receptor promoter. pro-areolas
  
• Authentic PM 1000mg (total).....up to 250 mg for women, days 1-14 (after periods ends)........pro-estrogen mimic, activates CYP2AB enzyme (necessary for feminization)
  
  
• Progesterone cream (applied to breasts, 3-4 times per week).....progesterone
  
• L-arginine (1 per day)........amino-acid, for activation of growth hormones signaling.
  
• reishi 1-2 (per day)........anti-androgen
  
• astaxanthin (1-2 per day)......anti-androgen
  
• niacin (inositol) 1-2 per day
  
• MSM, antioxidant, pro-breast health, GH (growth hormone) STAT5 protein synthesizer.......
  
  

Green Tea - stimulates beta-receptors at fat cells to increase release of lipids into the bloodstream. why is this important?, 95-98% fatty acids are bound in the blood stream (just like hormones are), we needed something that displaces hormones and fatty acids, looks like green tea is up for the task.




To be continued..........

[tanysquirrel]

thank you thank you thank you! an updated list *we are not worthy*   

[Lotus]

Never say never lol, I think my other side (who went down kicking and screaming lol) wouldn't let me experiment like this, HrT is working (me thinks).

[Sofia Bunny]

Never say never lol, I think my other side (who went down kicking and screaming lol) wouldn't let me experiment like this, HrT is working (me thinks).

Wow, just wow. Those pictures look amazing Lotus! Looks like that is a bit of a tight fit up top! How did you manage to squeeze yourself in? Again, amazing pictures. Thanks for sharing and making more people a tad more envious!