[myboobs]

...it's modifying DNA. And that's something I'm not going do blindly nor passively.

Modifying DNA? No. Messing with your endocrine system yes, but DNA is fixed and unchangeable.

FWIW I take my estradiol before bed and 1000mg PM when I wake hoping my estrogen is high in the morning as it is in genetic females AND present to offset testosterone as Pansy-Mae said. A little in the afternoon to keep it available and that's it. I agree with others though, it's not rocket science ...but if it is no one here is a rocket scientist.

Messing with your endocrine systems messes with your RNA which in turn can mess with aspects of your DNA. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC224261/)

By the way, it was not my intention to create a kerfuffle in this thread. I was just curious as to when people took PM and what people thought of the notion of the t-cycle in relation to taking PM. All I wanted to do was generate some data that could help answer a question; not attain empathy for Copernicus.

If you like your regime and it works for you, keep your regime. It's your body. I wasn't trying to say anything to the contrary.

And I do apologize if I have come off as prickly.

I believe in continuous learning . Nbe subject is not very well researched since there are no mega bucks to be made out of it . There is lot of research done which is out there but the information is fragmented. It is credit to LOTUS that he takes time to research and try to make sense of it for us mere mortals .

This information is not forced down anyone's throat , as it is individiual's choice as to accept it or not . The freedom of choice belongs to individuals.

The parallel I can draw is , if you are happy with ford model T , than why not !
But if you want a Ferrari than you have to get into niti griti .

That's my 2 penny's worth of useless twaddle