[Lotus]

PM lowers one's testosterone levels indirectly by increasing the amount of estrogen in the body (in this case miroestrol which mimics estradiol). When the body senses the higher level of estrogen, it removes an equal amount of free testosterone by binding it to SHBG (sex hormone binding globulin) making it unavailable. Any unbound androgens remaining are still able to do their intended function in the absence of a strong anti-androgen.

Please correct me if my understand is still off the mark.

Hugs,
Clara

I'm impressed!

Essentially, the signaling of excess estrogen is shutting down the AR receptor, or otherwise tricking the signal that it's produced enough, quite brilliant I'd say.

This is why I suggested that you didn't need a AA when you started your program. No, not just my opinion, research backed it up.

Just search the first paragraph of this and you'll see what I'm talking about:

High serum-High serum levels of estrogen also trick the brain into thinking that enough testosterone is being produced, further slowing its natural production. This happens when estrogen saturates testosterone receptors in the hypothalamus region of the brain. The saturated hypothalamus then stops sending out a hormone to the pituitary gland to stimulate secretion of luteinizing hormone that the gonads require to produce testosterone. High estrogen can thus shut down the normal testicular production of testosterone. A further complication of excess estrogen is that it increases the body's production of sex hormone-binding globulin (SHBG). SHBG binds free testosterone in the blood and makes it unavailable to cell receptor sites. The solution to this problem is to block the conversion of testosterone to estrogen


But, keep in mind everybody metabolizes E differently!