30-03-2014, 01:46 AM
(30-03-2014, 01:20 AM)myboobs Wrote:(30-03-2014, 12:58 AM)~Lotus~ Wrote: Remember in the first post of the thread this statement:Let me throw a spanner in the works .
Men produce 3mg to 10mg of T per day, and of that 4% gets converted to DHT and .02% gets converted to estrogen, (estradiol E2)
The prostate converts 95% of T to DHT by 5 alpha reductase, ( 5ar).
.02% of E is converted by the enzyme aromatase, this small percentage can be misleading, estradiol is 100 more potent at the receptor sites then T, that means T needs to balance at the same level to have the same affinity.
Although naturally-occurring estrogens circulate in the blood largely bound to sex hormone-binding globulin and albumin, only unbound estrogens enter target tissue cells. This statement is explaining Free E, exactly the same principle as FREE T and that also means E-receptors.
Below is what I'm talking about if anybody would like some supported info:
Testosterone-derived estradiol production by male endothelium is robust and dependent on p450 aromatase via estrogen receptor alpha.
http://www.springerplus.com/content/2/1/214
Since it is the pituitary gland that sends signals for production of various hormones and also signals for balancing any unbalances .
I was watching a health program where this guy's breast ( albeit small ) was producing milk , he was diagnosed by the doctor pituitary gland malfunction for which this guy had treatment .
So here is me thinking maybe we at NBE could look at manipulating the pituitary gland . As by doing that you are tackling the source rather than end product.
Is my logic correct ?
Well yes ,
Your logic is correct and assuming that the pituitary regulates homeostasis (control) over the endocrine, it's the master gland.
But that condition is called prolactinoma-its a benign tumor of the pituitary gland that produces a hormone called prolactin. It is the most common type of pituitary tumor. Symptoms of prolactinoma are caused by too much prolactin in the blood (hyperprolactinemia) or by pressure of the tumor on surrounding tissues.
The improper hormonal balance, or thyroiditis is big problems for NBE'ers, also cortisol in older bio-males has a great affect in the whole enzymatic (Aromatase) response if that's what you meant.

