[❇ Abby ❇]

At the moment I am researching if PM is Sublingual and Buccal.

Sublingual and Buccal Medications
Certain medications are placed under the tongue (sublingual) or between the teeth and the cheek (buccal). These medications are absorbed quickly into the bloodstream through the lining of the mouth and are used to relieve symptoms almost immediately.

This type of medication may also be ordered if the effects will be lessened during the digestion process. The cheek and the area under the tongue have a lot of capillaries, or tiny blood vessels. This means that the medication can be absorbed directly into the bloodstream without needing to go through your digestive system.

This means the drug is not metabolized through the liver, and thus a lower dose can be used.

Research still in progress.


Denita.

Sublingual and buccal medications are absorbed quickly into the bloodstream through the lining of the mouth.

All blood is filtered through the liver.

Capsules, tablets, powders, teas, etc. have to go through the digestive tract first. Then into the blood, then to the body with eventual filtering by the liver.

BigDave

A) Sublingual
Certain drugs are best given beneath the tongue or retained in the cheek pouch and are absorbed from these regions into the local circulation. These vascular areas are ideal for lipid-soluble drugs that would be metabolized in the gut or liver, since the blood vessels in the mouth bypass the liver (do not undergo first pass liver metabolism), and drain directly into the systemic circulation. This route is usually reserved for nitrates and certain hormones.

Denita