25-04-2014, 07:15 AM
You might find this study from Nutrition Research Journal interesting.
Bimodal action of miroestrol and deoxymiroestrol, phytoestrogens from Pueraria candollei var. mirifica, on hepatic CYP2B9 and CYP1A2 expressions and antilipid peroxidation in mice.
The aim of the present study is to investigate the impact of miroestrol and deoxymiroestrol (Fig. 1) on the regulation of hepatic CYP2B9 and CYP1A2 at both transcriptional and enzymatic levels. We hypothesized that because miroestrol and deoxymiroestrol have similar structures compared with estradiol and possess estrogenic-like activities, these 2 compounds should regulate mouse hepatic P450s in a similar manner as estradiol. Furthermore, the antilipid peroxidation activities of these 2 compounds were determined in the mouse brain to provide additional beneficial biologic activities.
Nutrition Research Journal
Happy Reading.
Denita
Bimodal action of miroestrol and deoxymiroestrol, phytoestrogens from Pueraria candollei var. mirifica, on hepatic CYP2B9 and CYP1A2 expressions and antilipid peroxidation in mice.
The aim of the present study is to investigate the impact of miroestrol and deoxymiroestrol (Fig. 1) on the regulation of hepatic CYP2B9 and CYP1A2 at both transcriptional and enzymatic levels. We hypothesized that because miroestrol and deoxymiroestrol have similar structures compared with estradiol and possess estrogenic-like activities, these 2 compounds should regulate mouse hepatic P450s in a similar manner as estradiol. Furthermore, the antilipid peroxidation activities of these 2 compounds were determined in the mouse brain to provide additional beneficial biologic activities.
Nutrition Research Journal
Happy Reading.
Denita