[Lotus]

I think this might be the original research.

Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra)


Denita

Ok Denita we need to talk about this:

One third of the fractions displayed estrogenic activity towards either one or both estrogen receptors (ERs; ERα and ERβ). Glabrene-rich fractions displayed an estrogenic response, predominantly to the ERα. Surprisingly, glabridin did not exert agonistic activity to both ER subtypes. Several fractions displayed higher responses than the maximum response obtained with the reference compound, the natural hormone 17β-estradiol (E2).