[GoneGirl]

Spiro blocks T receptors from linking to free T in the blood. The pituitary sees that there is sufficient free T, so it shuts down T production in the testes. But, since there is free T in the blood, it will get converted to DHT by the enzyme 5-alpha reductace. That's where finasteride and dutasteride come in because they reduce the amount of 5ar produced, thus limiting the amount of DHT that is converted.

Apparently, you are right about the dosage recommendations for spiro, Sarah. Spiro has a very short half life, so it needs to be taken more than once a day in sufficient amounts to keep the T receptors tied up. When I increase by dosage, I think I'll take another tablet at lunch time.

Clara