[GoneGirl]

LOL, for whatever reason, the talk about spiro invaded my brain and I just took another 100 spiro pill instead of the dutasteride I was supposed to.

So now thats 200mg of spiro in like 4 hrs! lol, i guess we'll see what happens.

Ooooh! Sarah, you'll be peeing all evening...giggle. So, to continue.....

Taking spiro doesn't reduce your T levels. Rather it prevents T from linking to androgen receptors throughout the body. In other words, it prevents free T and DHT from doing their thing. Free T affects the primary sex characteristics of a male, i.e., the reproductive organs, sex drive, muscular development. DHT affects the secondary sex characteristics which include hair follicles. Spiro's T blocking effect will be immediate if the dosage is sufficient.

But, in addition to blocking T, we want to lower our total serum T to about 40 ng/dL, that's about the amount that a GG has. This is best done by taking E2 (estradiol). If there is sufficient E2 in the blood, it will drive down T levels because the pituitary will not call for T production in the testes if there is sufficient sex hormone (E+T) in the blood.

The use of all three drugs (estrogen, spironolactone, and finasteride) work in combination to speed up feminization.

Clara