(25-06-2014, 06:56 PM)bobie Wrote: So in my search for knowledge i have come across several topics suggesting that spiro causes breast bud fusion
http://www.susans.org/forums/index.php?topic=154404.0
http://www.susans.org/forums/index.php/topic,158852.0.html
Tbh im a little worried right now and seriously considering just using estradiol and finasteride, thoughts on how likely the above is?
Quote:Finasteride inhibits Type 2 5 alpha-reductase (while Dutasteride also inhibits Type 1, there are only two types) which converts T to DHT (dihydrotestosterone), about 5x more potent than T and responsible for scalp hair loss and body hair growth (and prostate enlargement and probably many other things as well). If less T converts to DHT, then more T is available and some of that may be converted to E, thereby slightly increasing E levels. E does not convert back to T, it's only one way, always T to E. Finasteride and dutasteride do NOT block T or DHT.
Spiro and Cypro reduce androgen levels (and your own E since A converts to E) and block androgens (T, DHT and other weaker androgens) from binding to receptors. Cypro blocks androgen more strongly. Spiro also increases breakdown of androgens, and conversion of androgen to estrogen. Both Spiro and Cypro, being progestins, are also mildly anti-estrogenic and in rats/mices, somewhat androgenic (I don't know if it's the same for us).
E also reduces androgen and also apparently...
http://en.wikipedia.org/wiki/Polyestradiol_phosphate
"blocks testosterone uptake into prostate cells, where it would be metabolized to DHT by the enzyme 5α-reductase. Estradiol also inhibits 5α-reductase directly, blocks binding of DHT to androgen receptors, and exhibits cytotoxicity on prostate cancer cells.[4][7]"
So there you go.
Bobie, every time I read things like this when someone brings up what a doctor states it has a ripple effect. You can't access the report, I'd suggest possibly doing more research on it, I try to gather all the evidence, make comparisons and then make an informed decision.
Imo regardless of being on NBE or pharma is not to reduce free T, converting to E is a viable option, so again why suppress the one thing to which is the basis of breast growth and feminization.
The science of this is staring us right in the face!