[EvaMarie]

Here's a study among many Ive read read concerning smoking and oral estrogen metabolism... I can just tell you how I can feel the difference with transdermal E

One thing Ive wondered though is how smoking effects PM metabolism??? I do know I needed up to 5000mg PM to really see results and feel good

YES I know I should just quit smoking

However, it has been proven that, depending on the type, duration and intensity of nicotine consumption, smoking can reduce or completely cancel the efficacy of orally administered estrogens. Not only does smoking diminish the otherwise well-established beneficial effects of estrogen on hot flashes and urogenital symptoms and its positive effects on lipid metabolism, i.e. by reducing cholesterol, but smoking also specifically reduces estrogen's ability to prevent osteoporosis. The reduction or loss of therapeutic efficacy is mainly caused by dose-dependent elevated hepatic clearance, partially in conjunction with lower estrogen levels, and has been demonstrated only with oral estrogen applications.

http://www.ncbi.nlm.nih.gov/pubmed/15638743

http://www.researchgate.net/publication/8092083_Smoking_estradiol_metabolism_and_hormone_replacement_therapy/file/9fcfd5091226151133.pdf