[Candace]

I think US20050048129 is their patent application, and I can see why it has never been granted. There are no examples, data, reduction to practice, mechanistic studies etc.

So how do people think the permanent effect works? Is there an epigenetic change (say, in DNA methylation or histone acetylation) that increases aromatase expression in the testes? Perhaps aromatase promoter II (the promoter that works in the gonads) gets upregulated?