[Dynseli]

Ok Lovely, you've got me thinking, here's something to ponder: (a theoretical powerhouse aromatase formula, lol)........

Add oats to your program because it down-regulates SHBG and up-regulates free testosterone, then add an aromatase booster (WP), a 5 ar-inhibitor (PSO, reishi, etc), DHEA (low dose) to up-regulate hormones (btw, maca upregulates dhea).

This study makes makes me go off into the deep end, and now I'm on the curve.

http://www.ncbi.nlm.nih.gov/pubmed/23416106
Interaction of Androst-5-ene-3β,17β-diol and 5α-androstane-3β,17β-diol with estrogen and androgen receptors: a combined binding and cell study.

That formula is good with the idea of maca and oats. I was proposing using estriol converstion by using milk thistle to possibly help the liver convert estradiol into estriol. The liver enzyme 16alpha-OHase is important. Estriol is safer than estradiol, and it's more bioavailable.

That study says those andro compound metabolites reduce cancer. This is good, and 16alpha-OHase, helps the conversion of DHEA into other compounds, all the way to estriol. 16alpha-OHase even converts estradiol and estrone directly into estriol. There are many pathways that involve 16alpha-OHase to estriol.

[Low-Dose DHEA Increases Androgen, Estrogen Levels in Menopause' - Fertil Steril. 2003;80:1495-1501]

'"Although DHEA supplementation is not yet considered a medical treatment, this steroid has been demonstrated to induce specific metabolic effects and to increase both androgen and estrogen plasma levels in postmenopausal women," write Alessandro D. Genazzani, MD, PhD, and colleagues from the University of Modena in Italy.
...
All patients took 25 mg/day DHEA supplementation for 12 months. Every three months throughout the trial period, the investigators evaluated patients and drew blood samples to determine plasma levels of LH, FSH, E 2, DHEA, DHEAS, androstenedione (A), testosterone, dihydrotestosterone, progesterone, 17 alpha-hydroxyprogesterone (17-OHP), allopregnanolone, estrone (E1), sex-hormone binding globulin (SHBG), cortisol (F), beta-endorphin, growth hormone (GH), and insuline-like grown factor-1 (IGF-1).
...
Testosterone and dihydrotestosterone plasma levels, and plasma E 1 and E 2 levels increased significantly and progressively in both groups. Investigators found no changes in SHBG concentrations in either group despite significant changes in A and E plasma concentrations. Allopregnanolone and beta-endorphin concentrations significantly increased in both groups.
...
Cortisol F plasma levels progressively decreased throughout the study. Both groups also experienced significantly reduced LH and FSH plasma levels. GH and IGF-1 levels significantly increased in both groups. Supplementation did not induce changes in endometrial thickness.
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Scores significantly improved in both groups during therapy.
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"The present study demonstrates the efficacy of low-dose DHEA administration of endocrine and psychoneuroendocrine parameters in early and late menopause and confirms that a low-dose DHEA supplementation increases adrenal androgens plasma levels (mainly DHEA and DHEAS), which are significantly impaired during menopause," Dr. Genazzani and colleagues write.
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"These data support and confirm that DHEA must be considered a valid compound and drug for [hormone therapy] in postmenopausal women and not just a 'dietary supplement,' " they add.'

Trimmed down to important parts of the study,

applying Borage oil could work too, tea tree was listed in a study if I remember, they reported Gyno in young men (or boys?). lavender sounds promising.

Tea tree and lavender are both implicated in gynecomastia. Here is the thread with important links http://www.breastnexus.com/showthread.php?tid=21618 'Lavender and Tea tree oil for external use only ' to prove it.

I think tea tree, lavender or aromatases are useful applied topically. Think about it, let aromatase conversion reduce androgens near the skin next to breast tissue. I'm unsure if lavender or tea tree are aromatases, but there is evidence that they function well topically.

Liver health is very important, first of all for overall health, and secondly it uses the enzyme 16a-OHase to break down estradiol into the more bioavailable estriol. Does Milk thistle support this function?

Aromatase mostly takes care of estrogens. There are also progestogens and prolactin.

Agreed, liver health and NBE ultimately go hand in....well, you know what I mean. I'm sure you've heard about E getting absorbed back into the system before elimination and possibly causing toxic and unwanted effects. Milk Thistle and Dandelion root help with healthy E metabolism.
Comparative Measurements of Serum Estriol, Estradiol, and Estrone in Non-pregnant, Premenopausal Women: A Preliminary Investigation

http://www.anaturalhealingcenter.com/documents/Thorne/articles/Estriol_Estradiol_Estrogen.pdf

http://www.altmedrev.com/publications/3/2/101.pdf 'Estriol: Safety and Efficacy' (repost) This paper is very important. It has a chart that shows the pathways and enzymes, that go from DHEA, Androstenedione, estradiol, esterone to estriol. 16alpha-OHase, a liver enzyme, is in many paths. The paper also says estriol has less risk of cancer than estradiol. You once wrote that estradiol had a problem with binding to SHBG, and estriol doesn't bind as much to SHBG. Even if estriol is less potent than estradiol, it is more bioavailable. I was proposing using milk thistle to help the liver, and to help it convert estradiol into estriol. Your proposed formula is very good, but I suggest adding 16alpha-OHase or a liver protector to that plan. I think estriol is better for NBE than estradiol.

I just had an eureka moment. You know that progesterone and prolactin both lower estradiol. What If these two hormones help break down estradiol into estriol? Progesterone, and prolactin also cause gains on their own.