27-09-2014, 11:39 PM
From the linked research that was posted I find this study interesting in the fact that Estriol concentrations were increased during menstrual cycles. And this statement in particular:
The second data set presents the estrogen levels of five women on different days of their menstrual cycles (Table 2). Because this was a preliminary study and the date of the estriol peak was unknown, the five subjects were tested at different times of the cycle. Subject 1 had blood drawn on the 7th, 10th, 14th, 17th and 24th days of the cycle. The estrogen quotient was lowest (EQ 7.1) on day 7 and increased to a high of 14.5 on day 24. Subject 2 was tested on the 7th, 12th and 21st days of the cycle. The estriol concentration followed a slight upward slope, but due to a peak in the estrone and estradiol concentrations, the EQ reached a minimum of 9.2 on the 12th day of the cycle. Subject 3 also exhibited an increase in estriol level as the cycle progressed; how- ever, the EQ was nearly the same on the 4th and 10th day (8.4 and 7.4 respectively), but due to a drop in estradiol and estrone on the 19th day, the EQ rose sharply to 17.7. Subject 4 had the earliest data point — the 2nd day of the cycle. The estrone and estradiol were both very low which was to be expected (1 pg/mL and 7 pg/mL respectively), but interestingly the es- triol remained fairly high at 303 pg/mL, yield- ing a very high EQ of 37.9. Subject 5 had samples drawn on the 8th, 10th and 26th day of the cycle. The EQ regressed from 14.0 on day 8 down to 7.9 on day 10 and soared to 29.1 on day 26 (the latest day of the cycle in our study).
Conclusion
The fractionated estrogen concentration data from the population of 26 women shows that the estriol in every case was at least three times as great as the concentration of estradiol and estrone combined. In fact, the average EQ for the population was 8.9. With estriol circulating at nearly 10 times the concentration of estrone and estradiol, it appears at least a possibility that there must be unknown significant biological activity for this “weaker” hormone. (One might draw a parallel with the history of DHEA research).
The conclusion that may be obtained from the five-women research project inves- tigating fractionated estrogen concentrations at different times of the menstrual cycle is that estriol is in higher concentration than both estrone and estradiol every day of the cycle that this study tested. It was observed that very early in the cycle (day 2) and very late in the cycle (day 26) the two subjects had very high Estrogen Quotients. As we know, estrone and estradiol are very low both late and early in the cycle, but it is very interesting to see that estriol does not seem to display the same proportionate drop in concentration.
The findings of this study necessitate additional research including more patients, more data points over the span of the cycle, and urine fractionated estrogen studies.
For more information on therapeutic applications of estriol see: Estriol: Safety and Efficacy. Altern Med
http://www.anaturalhealingcenter.com/documents/Thorne/articles/Estriol_Estradiol_Estrogen.pdf
Apologies for drifting of topic.
Quote:With estriol circulating at nearly 10 times the concentration of estrone and estradiol, it appears at least a possibility that there must be unknown significant biological activity for this “weaker” hormone.
The second data set presents the estrogen levels of five women on different days of their menstrual cycles (Table 2). Because this was a preliminary study and the date of the estriol peak was unknown, the five subjects were tested at different times of the cycle. Subject 1 had blood drawn on the 7th, 10th, 14th, 17th and 24th days of the cycle. The estrogen quotient was lowest (EQ 7.1) on day 7 and increased to a high of 14.5 on day 24. Subject 2 was tested on the 7th, 12th and 21st days of the cycle. The estriol concentration followed a slight upward slope, but due to a peak in the estrone and estradiol concentrations, the EQ reached a minimum of 9.2 on the 12th day of the cycle. Subject 3 also exhibited an increase in estriol level as the cycle progressed; how- ever, the EQ was nearly the same on the 4th and 10th day (8.4 and 7.4 respectively), but due to a drop in estradiol and estrone on the 19th day, the EQ rose sharply to 17.7. Subject 4 had the earliest data point — the 2nd day of the cycle. The estrone and estradiol were both very low which was to be expected (1 pg/mL and 7 pg/mL respectively), but interestingly the es- triol remained fairly high at 303 pg/mL, yield- ing a very high EQ of 37.9. Subject 5 had samples drawn on the 8th, 10th and 26th day of the cycle. The EQ regressed from 14.0 on day 8 down to 7.9 on day 10 and soared to 29.1 on day 26 (the latest day of the cycle in our study).
Conclusion
The fractionated estrogen concentration data from the population of 26 women shows that the estriol in every case was at least three times as great as the concentration of estradiol and estrone combined. In fact, the average EQ for the population was 8.9. With estriol circulating at nearly 10 times the concentration of estrone and estradiol, it appears at least a possibility that there must be unknown significant biological activity for this “weaker” hormone. (One might draw a parallel with the history of DHEA research).
The conclusion that may be obtained from the five-women research project inves- tigating fractionated estrogen concentrations at different times of the menstrual cycle is that estriol is in higher concentration than both estrone and estradiol every day of the cycle that this study tested. It was observed that very early in the cycle (day 2) and very late in the cycle (day 26) the two subjects had very high Estrogen Quotients. As we know, estrone and estradiol are very low both late and early in the cycle, but it is very interesting to see that estriol does not seem to display the same proportionate drop in concentration.
The findings of this study necessitate additional research including more patients, more data points over the span of the cycle, and urine fractionated estrogen studies.
For more information on therapeutic applications of estriol see: Estriol: Safety and Efficacy. Altern Med
http://www.anaturalhealingcenter.com/documents/Thorne/articles/Estriol_Estradiol_Estrogen.pdf
Apologies for drifting of topic.