Coffee=Confusing, oh boy!!!! 
The liver detoxifies caffeine using the CYP1A2 enzyme system, which is also responsible for initial metabolism of estrogen during Phase I clearance by the liver. This is one reason caffeine is likely metabolized more slowly in women taking oral contraceptives or postmenopausal hormone replacement therapy.
While research showing the effects of chronic caffeine consumption on circulating levels of estrogen isn’t yet available, researchers have suggested that caffeine consumption may lower the risk of breast cancer by upregulating the CYP1A2 isoenzyme and thus improving estrogen metabolism.
So, the jury is temporarily out to lunch.
Putting it all together
No known studies demonstrate statistically significant correlations between coffee over-consumption and the unwinding of the neuroendocrineimmune system. We just don’t know for sure yet how all the puzzle pieces fit together.
However, certain theoretical pathways can be created, and have been observed clinically. We can also make some informed speculation based on what we already know of the neuroendocrineimmune system’s interrelationships.
http://www.precisionnutrition.com/coffee-and-hormones
My brain is hurting, lol, I'll do battle with caffeine and coffee another day.
The liver detoxifies caffeine using the CYP1A2 enzyme system, which is also responsible for initial metabolism of estrogen during Phase I clearance by the liver. This is one reason caffeine is likely metabolized more slowly in women taking oral contraceptives or postmenopausal hormone replacement therapy.
While research showing the effects of chronic caffeine consumption on circulating levels of estrogen isn’t yet available, researchers have suggested that caffeine consumption may lower the risk of breast cancer by upregulating the CYP1A2 isoenzyme and thus improving estrogen metabolism.
So, the jury is temporarily out to lunch.
Putting it all together
No known studies demonstrate statistically significant correlations between coffee over-consumption and the unwinding of the neuroendocrineimmune system. We just don’t know for sure yet how all the puzzle pieces fit together.
However, certain theoretical pathways can be created, and have been observed clinically. We can also make some informed speculation based on what we already know of the neuroendocrineimmune system’s interrelationships.
http://www.precisionnutrition.com/coffee-and-hormones
My brain is hurting, lol, I'll do battle with caffeine and coffee another day.
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