[Misty0732]

I do think PM could be the cause of our fasciculations if it is contributing to pseudo estrogen dominance. (I say "pseudo" because PM does NOT contain estrogen, but it obviously has strong estrogenic effects in humans and conceivably could cause symptoms similar to true estrogen dominance via it's effect on LH/LSH and testosterone. If you search for the symptoms of estrogen dominance, you will find hypothyroidism is a frequently near the top of the list. If you do a search on fasciculations and hypothyroidism, again, fasciculations are frequently a symptom of hypothyroidism as either a sequelae of the effect on energy metabolism and/or electrolyte imbalance in the muscle tissue.

Thanks for the input, chrishoney! I was actually starting to wonder if I might be estrogen dominant and was ready to post such a question on this forum. I had recently increased (doubled) my PM intake from 1500mg/day to 3000mg/day, and I don't use any progesterone product at all. I have had the fasciculations for well over a year but they have definitely increased lately (a lot) and could correspond to around the time I increased the dosage.

Also, the combination of PM and statins could create the problems you are having. Think of fasciculations as a kind of subclinical myopathy. Also realize, the myopathy associated with statins can run the gamut from intense pain to minor aches and the like.

If this is the case then I hope adding progesterone and reducing the dosage of PM eliminates the twitching. If not I will probably have to go off PM and live with the GD (not a pleasant thought)...

The primary way GG's counter estrogen dominance is to take supplemental progesterone. You could lower your PM dosage and/or add progesterone to your program. I think you might find the fasciculations and/or cramps (if you're having any) will significantly decrease.

Is topical progesterone cream the way to go here? I could pick up some today at GNC if I knew what to get. Also, is this something I would need to use only part of the time (it seems I read somewhere that the progesterone should be used to simulate a period, and only for a week to 10 days a month)?

I appreciate any help anyone can give me here... the twitching is driving me to drink! (Heavily...)

Thanks

Misty