[Misty0732]

JJ-

I hate to break it to everyone but the lower dose is the one that provides the most results, and the higher doses actually increase the anti-estrogenic response.

See this study:

Differtial Binding with ERa and ERb of Phytoestrogens rich plant Pueraria Mirifca
http://www.scielo.br/scielo.php?pid=S0100-879X2009007500026&script=sci_arttext&tlng=pt#Fig2


Higher dosages just turns out to be a placebo effect.

Hmm... that's not what I take from the article. The article seems to suggest that high doses of phytoestrogens causes an anti-estrogenic response since the weaken phytoestrogens fill the estrogen receptors and hence prevent the "real" estrogen from binding. In the case of genetic males (with extremely low amounts of estrogen) an increase in PM would not act in the same way (at least until all the available receptors are filled). In most GMs the majority of estrogen receptors are unfilled.

OK, this is a bit simplistic but that's how I understand it. I could be completely misinterpreting the article as I skimmed it pretty quickly...

Misty