08-01-2015, 04:22 PM
When I last used PM, some years ago, I was on 2000mg per day. When I had my blood tested prior to stopping PM and going onto Estradiol my tests showed nothing estrogenic, but my SHBG levels were very high.
SHBG is a hormone that mops up sex hormones and takes most of them out of circulation. My endo told me that my SHBG was responded to the herbal estrogen and removing all of it that my body was not using. In short, if it did not bind to the estrogen receptors then SHBG mopped it up and broke it into metabolites for excretion. SHBG mops up DHT then T then E.
There really is no point in overdosing on this stuff because your body will not use the excess. The old advice of "stop ramping up the dose when you start getting results" is the best advice.
Estradiol E2 ß has a half-life in circulation of 17 hours. Testostoreone has a half life of 43 minutes. I do not know what the half life of PM in circulation is but it is probably similar to E2 as it is an E2-like compound (thus why it works).
SHBG is a hormone that mops up sex hormones and takes most of them out of circulation. My endo told me that my SHBG was responded to the herbal estrogen and removing all of it that my body was not using. In short, if it did not bind to the estrogen receptors then SHBG mopped it up and broke it into metabolites for excretion. SHBG mops up DHT then T then E.
There really is no point in overdosing on this stuff because your body will not use the excess. The old advice of "stop ramping up the dose when you start getting results" is the best advice.
Estradiol E2 ß has a half-life in circulation of 17 hours. Testostoreone has a half life of 43 minutes. I do not know what the half life of PM in circulation is but it is probably similar to E2 as it is an E2-like compound (thus why it works).