[Lotus]

Excellent point ia,

I suppose some of the reasoning behind large doses stems from the theory of overcoming testosterone (which I bought into). The problem with that is just because males have a larger liver doesn't make it any less susceptible to damaging it. But, if your able to fork over the 6 figures required for a liver transplant by all means knock yourself out, only there's a huge waiting list for the people who actually need one.

Now the information about taking less gets more isn't new, in fact it's documented quite well. Here's something that isn't well documented, an over expression of estrogen will send the enzyme armomatase (which converts testosterone to estrogen) back into testosterone.

Higher dose of estrogen slows down aromatase in MTF's, granted PM is an estrogenic mimic, it's at least 25% of E2 as been reported, which doesn't mean I need to take 75% more. I've learned the hard way on stressing out my body on those higher doses I thought would work. That fact I've grow more with less (and documented it) says the science is correct. But that's just my opinion, it's also my opinion if you report having problems with taking large doses of PM why do we still endorse it.
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Even though I'm not interested in transitioning I think we need to use the same research as it still effects the very basics of GM's wanting to grow breasts.

http://www.camh.ca/en/hospital/care_program_and_services/hospital_services/Documents/hormones-MTF.pdf

Thanks JJ, I like reading your posts too.