[EvaMarie]

Excellent point ia,

I suppose some of the reasoning behind large doses stems from the theory of overcoming testosterone (which I bought into). The problem with that is just because males have a larger liver doesn't make it any less susceptible to damaging it. But, if your able to fork over the 6 figures required for a liver transplant by all means knock yourself out, only there's a huge waiting list for the people who actually need one.

Now the information about taking less gets more isn't new, in fact it's documented quite well. Here's something that isn't well documented, an over expression of estrogen will send the enzyme armomatase (which converts testosterone to estrogen) back into testosterone.

Higher dose of estrogen slows down aromatase in MTF's, granted PM is an estrogenic mimic, it's at least 25% of E2 as been reported, which doesn't mean I need to take 75% more. I've learned the hard way on stressing out my body on those higher doses I thought would work. That fact I've grow more with less (and documented it) says the science is correct. But that's just my opinion, it's also my opinion if you report having problems with taking large doses of PM why do we still endorse it.
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Even though I'm not interested in transitioning I think we need to use the same research as it still effects the very basics of GM's wanting to grow breasts.

http://www.camh.ca/en/hospital/care_program_and_services/hospital_services/Documents/hormones-MTF.pdf

Thanks JJ, I like reading your posts too.

Hi Lotus its my understanding that its impossible to convert E to T it just doesnt work that way... The goal with MtF HRT is to reduce T to female levels so the E can work unopposed... Taking a high dosage of E will not result in more T, it will result in less... I can confirm that with firsthand experience and lab work to back it up... Now its debatable that a high level of E is needed or desirable... Without a doubt though T is poison to someone in transition though... Im on a 5ar (DHT) blocker (Dutasteride) and Spiro (blocks AR's and increases aromataze, and blocks conversion of P to T) along with P... P is the most muddy as far as info I can find, there just isnt much out there thats conclusive at all... While P can be converted to T it just doesnt happen for me, Im not not sure it can in my case and again its impossible for E to be metabolized to T...

Certainly amazing feminization is possible on low dose HRT for some people and Im usually quite jealous of them

BUT NBE isnt quite "syn HRT" and with those poison factorys attached and functional yes I can see the argument that "less is more".... Im not sure how it works but they will "fight back" as long as the body is wired to be male... I'll admit NBE is a mystery to me but it certainly can and does amazing things as you and others here have shown

The fact that PM got my tits started while my T measured in the lower normal range always boggled my mind... There must be some kind of a androgen receptor blocking mechanism at work there along with an aromataze and estrogenic effect... Its amazing stuff, I can still feel the effect of PM even on high dose HRT