At the very least, I think we need a combo of an oral and sublingual approach, transdermal would work too. Sublingual/transdermal for targets tissues, (escaping the first pass metabolism for the most part), low dose E for liver metabolism. Add fatty acids for 5 AR's and aromatase, and the standard AA of choice, PC in addition, massage, light aerobics, and mini detox 1x per month. Of course proper nutrition, fresh fruits, greens, healthy nuts (fatty acids again) PUFA's-polyunsaturated fatty acids like walnuts, coconut-oil etc, vitamin C helps E metabolize.
Just my opinion.
Just my opinion.

