(26-03-2015, 11:07 PM)-Clelia- Wrote: I've got to go now. I know that i still miss something, i'll come back next week, i'm off for the weekend. see you!

Clelia,

You give good homework assignment too. I look forward to hearing from you , have a good weekend.

Oh btw, science is cruel mistress, just when I think I've figured out how chaperone proteins work or dimers in the cytoplasm, or even receptor initiated gene transcription, wham....smack-smack upside my head, she has other plans, then it hits me!!!, duh!!!.....depolarization and repolarization of sodium and calcium ion channels, phew!!!! Estradiol has a direct effect on G-coupled protein recepotrs, besides the ion channels. Its still painting the picture in my mind how cells diffuse across membranes, (well....actually two membranes), then into the cytoplasm.

I like this statement from a recent research article:

"Only by understanding completely the mechanisms and impact of estradiol action on the developing brain can we also understand when these processes go awry."