well done Lotus, these findings about ER receptor, are very interesting! I need to study a bit, compare some studies, then I will come back here. Differences in physiology can explain different results with the same compound (ex. Genistein), also our receptors exist in "strong or weak version", then more ore less signal response to molecules. Moreover, there is 35% of population that has not the enzimatic process which converts and activate genisteine and daidzeine (they both need to cut off the glycone, to be active), this occurs in the gut. Phytoestrogen also act in opposite way, before and after menopause. I will report links later, because im using a mobile now. We need to make things clear, from the whole information. See you!