One way in which a glucose carrier can be driven by a Na+ gradient
http://www.ncbi.nlm.nih.gov/books/NBK26896/figure/A2008/?report=objectonly

Carrier Proteins and Active Membrane Transport
In these systems, the solute and Na+ bind to different sites on a carrier protein. Because the Na+ tends to move into the cell down its electrochemical gradient, the sugar or amino acid is, in a sense, “dragged” into the cell with it. The greater the electrochemical gradient for Na+, the greater the rate of solute entry; conversely, if the Na+ concentration in the extracellular fluid is reduced, solute transport decreases.
http://www.ncbi.nlm.nih.gov/books/NBK26896/



sugar or amino acid is, in a sense, “dragged” into the cell with it, ok.....so sugar and amino acids up-regulates ion channels and NA+ down regulates?.