[Lotus]

That's good idea adding k2, how do you supplement it?, I tried grass fed butter in some coffee that Pom suggested, not bad. Egg yolks, gouda and brie cheese are other sources of k2 from what I've read.

That study is a good find (thanks). A healthy immune system is a big priority in NBE for sure. Mine went haywire when I pushed too hard.

ER-beta is in the bones, which is tied into NBE response elements, cancer too. I recently came across that B2 improves ER-a sensitivity.

Everything I read had Vitamin D increasing "total and free T", which imo can be a good thing since E comes from T. The androstenedione pathway converts T to E1 then to E2 and back again to E1. DHT which I understood had no value in NBE takes a exit pathway that possibly has a ER-beta link. (too funny).

It does seem odd why aromatase therapy wouldn't be included with HRT more often. Some treatment protocols for gynecomastia will include aromatase inhibitors with T therapy as a way to control runaway T. The initial supra therapeutic dosage of testosterone gets dumped into E in some cases of gyno, probably more often than not.

You can hardly find any related nbe info on pro-aromatase, when search terms are "promoter gene/expression" the yield is somewhat better, mostly it's about AI's. But here recently I think aromatase comes in many disguises , e.g. 17 beta HSD's, NAPHD (it's another enzyme), NO2 (nitric oxide), a few others too, heck I'd even call the androstenedione pathway an aromatase.

Btw, I'm glad you came out of moth balls, welcome back.

Okay, so, I read through this entire thread. I have just one question: what form of white peony would one use? I did a quick search on Google and it is available as a tea, liquid extracts, and 'immune support' capsules.

Liquid extract would obviously work best as a topical treatment, but which of the other two is better for oral administration?

The tea isn't white peony, it's white tea, (credit Amber). The real WP exists in extract or capsule form, life extension has a capsule brand, extract blends are pretty popular. But, I'd spread the dosage over 3-4 times in a typical day, for instance.....15 minutes after each dose of E2, which is about the time it's metabolized. This way, the influence of aromatase is shifted away to form DHT, which as we all know DHT will ruin a perfectly good day of E2.

Btw, vitamin C improves the bioavailability of E2, so does egg whites.