(15-07-2014, 04:30 AM)lovely11 Wrote: Bound testosterone must be SHBG. Bound estrogen and testosterone must bind to proteins in the blood steam instead of breast protein receptors. DHT must be different than SHBG. SHBG seems inactive, and DHT seems potent. SHBG might be good for inhibiting free T from converting into DHT.

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(15-07-2014, 04:13 AM)Lotus Wrote: Roughly 60% of circulating estradiol is derived from direct testicular secretion or from conversion of testicular androgens. The remaining fraction is derived from peripheral conversion of adrenal androgens [15].

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Testicular or ovaries by different amounts.

(23-03-2014, 10:08 PM)Lotus Wrote: So what is Free Testosterone?



Free T is testosterone that is present within the bloodstream or not bound (locked) to a chemical called albumin. But it's also the functional T, If we were to breakdown testosterone say like how we know estrogen is, i.e.. E1, E2, E3,

Generally,

FT-Free T is about 2% (this is the functional T)

BT-Bound T or 98%
-which is 38% albumin (bloodstream)
-SHBG is 60% (sex-hormone-binding-globulin)

This is complicated, however I'd like find an illustration where 5-ar and aromatase are expressed at the same time and to which pathway it takes within a cell receptor site.